Treatment of herpes simplex virus infection: rationale for occlusion.
Treatment of herpes simplex virus infection: rationale for occlusion.
复制标题
DOI：
10.1097/01.asw.0000280199.58260.62
复制
发表时间：
2007-07-01
影响因子：
2.4
通讯作者：
Kirsner, Robert S
中科院分区：
文献类型：
--
作者：
Patel, Asha R;Romanelli, Paolo;Kirsner, Robert S
口腔面部疱疹是一种广泛传播的良性疾病，也通常被称为唇疱疹或唇疱疹。这种类型的疱疹通常是由1型单纯疱疹病毒(HSV-1)和较小程度的2型单纯疱疹病毒(HSV-2)引起的，这两种病毒都是DNA病毒。疱疹皮损的临床表现通常位于面部的黏膜皮肤区，最终可能会侵蚀和溃烂，留下已知难以成功治疗的伤口。治疗的重点一直与病毒感染的治疗有关，而对由此造成的伤口的关注有限。临床观察和最近的组织学评估表明，这些伤口可以通过破裂的皮肤基底膜延伸到真皮，这表明HSV能够导致部分厚度的伤口。这一观察表明，闭塞在治疗疱疹引起的部分厚度创面中具有一定的作用，因为闭塞被公认为其他类型的部分厚度创面的首选治疗方法。
Orofacial herpes is a widespread benign malady that is also commonly known as herpes labialis or cold sores. Herpes of this type is generally caused by herpes simplex virus type 1 (HSV-1) and, to a lesser degree, herpes simplex virus type 2 (HSV-2), both of which are DNA viruses. The clinical presentation of herpetic lesions is normally located on mucocutaneous areas of the face and may eventually erode and ulcerate, leaving wounds that are known to be difficult to successfully treat. Focus of treatment has been related to treatment of the viral infection, and limited attention has focused on the resultant wounds. Clinical observation and recent histologic evaluation has demonstrated these wounds to extend through a disrupted cutaneous basement membrane into the dermis, suggesting that HSV is capable of causing partial-thickness wounds. This observation suggests a role for occlusion in the treatment of herpetic-induced partial-thickness wounds because occlusion is well recognized as the treatment of choice for other types of partial-thickness wounds.