Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study.
Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study.
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DOI：
10.1097/00001648-199009000-00003
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发表时间：
1990-09-01
期刊：
影响因子：
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通讯作者：
Garfinkel, L
中科院分区：
文献类型：
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作者：
Boffetta, P;Garfinkel, L
我们研究了适度饮酒者的总死亡率和冠心病（CHD）死亡率是否低于不饮酒者。在1959年参加美国癌症协会前瞻性研究的276，802名40-59岁的美国男性中，在随后的12年中发生了42，756例死亡，其中18，771例死于CHD（3%的队列失访）。以不饮酒者（55.3%）为参照组，按年龄和吸烟分层的总死亡率相对危险度（RR），偶尔饮酒者为0.88，每天饮酒1杯者为0.84，每天饮酒2、3、4、5和6杯或更多者分别为0.93、1.02、1.08、1.22和1.38。冠心病死亡的RR分别为0.86、0.79、0.80、0.83、0.74、0.85和0.92。多变量分析未能识别其他混杂因素。通过排除入组时健康状况不佳或有慢性病史的受试者（队列的32.8%）或排除在前6年随访期间死亡的受试者，未引入RR变化。这些数据表明，适度饮酒对冠心病死亡率有明显的保护作用，这不能归因于将患有冠心病或相关疾病的受试者纳入非饮酒者类别。
We studied whether moderate alcohol drinkers have a lower total and coronary heart disease (CHD) mortality than nondrinkers. Among 276,802 U.S. men aged 40-59 enrolled in 1959 in an American Cancer Society prospective study, 42,756 deaths, 18,771 from CHD, occurred during the following 12 years (3% of the cohort was lost to follow-up). Using nondrinkers (55.3% of the cohort) as a reference category, age- and smoking-stratified relative risks (RR) of total mortality were 0.88 for occasional drinkers, 0.84 for those drinking 1 drink per day, 0.93, 1.02, 1.08, 1.22, and 1.38 for those drinking 2, 3, 4, 5, and 6 or more drinks per day, respectively. RRs of CHD mortality were 0.86, 0.79, 0.80, 0.83, 0.74, 0.85, and 0.92, respectively. Multivariate analysis failed to identify other confounders. No changes in RRs were introduced by excluding subjects with poor health or history of chronic disease at enrollment (32.8% of the cohort) or excluding subjects who died during the first 6 years of follow-up. These data indicate an apparent protective effect of moderate alcohol intake on CHD mortality that cannot be attributed to the inclusion of subjects with CHD or related diseases into the nondrinker category.