A comparison of an immunological faecal occult blood test Fecatwin sensitive/FECA EIA with Haemoccult in population screening for colorectal cancer.
A comparison of an immunological faecal occult blood test Fecatwin sensitive/FECA EIA with Haemoccult in population screening for colorectal cancer.
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DOI：
10.1038/bjc.1985.124
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发表时间：
1985-06
影响因子：
8.8
通讯作者：
James, P D
中科院分区：
文献类型：
--
作者：
Armitage, N;Hardcastle, J D;Amar, S S;Balfour, T W;Haynes, J;James, P D
向3225名无症状个体提供了两种粪便潜血试验，一种是简单的化学试验，一种是血隐血试验，另一种是免疫学试验，即Fecatwin Sensitive/FECA EIA，作为结直肠癌的筛查。1,304人(44%)完成并退回了检测，其中126人(9.7%)被发现为阳性--隐血40人(3%)，FECA EIA106人(8.1%)。共检出癌5例(Dukes‘A期4例，Dukes’C期1例)和大于1 cm的腺瘤23例，筛查率分别为3.8/1000人和17.7/1000人。在确诊的5例癌症中，5例FECA EIA阳性，3例血隐血阳性。在23例直径大于1 cm的腺瘤中，J1例FECA EIA阳性，20例血隐血阳性。对78例FECA EIA阳性受试者进行调查，未发现肿瘤性疾病。虽然这种敏感的免疫测试增加了癌症的发生率，但高的假阳性率使其不适合目前形式的结直肠癌人群筛查。
Two faecal occult blood tests, a simple chemical test Haemoccult and an immunological test, Fecatwin Sensitive/Feca EIA, were offered to 3,225 asymptomatic individuals as screening for colorectal cancer. One thousand three hundred and four (44%) completed and returned the tests and of these 126 (9.7%) were found to be positive - Haemoccult 40 (3%) and Feca EIA 106 (8.1%). Five cancers (4 Dukes' Stage A, 1 Dukes' Stage C) and 23 adenomas greater than 1 cm were detected - rates of 3.8 per 1000 persons screened and 17.7 per 1000 persons screened respectively. Of the five cancers identified 5 were Feca EIA positive and 3 were Haemoccult positive. Of the 23 adenomas greater than 1 cm diameter identified, J1 were Feca EIA positive and 20 were Haemoccult positive. Seventy-eight Feca EIA positive subjects were investigated and no neoplastic disease was identified. Whilst this sensitive immunological test increases the yield of carcinomas, the high false positive rate makes it unsuitable for population screening for colorectal cancer in its present form.