Systemic Sclerosis Gastrointestinal Disease and Its Management
Systemic Sclerosis Gastrointestinal Disease and Its Management
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DOI：
10.1016/j.rdc.2015.04.007
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发表时间：
2015-08-01
影响因子：
2.3
通讯作者：
Baron, Murray
中科院分区：
文献类型：
--
作者：
Gyger, Genevieve;Baron, Murray
胃肠道影响超过90%的患者，是系统性硬化症最常累及的内脏器官。胃肠道的任何部分都可能受到影响，从口腔到肛门。患者通常会经历生活质量下降和社交生活受损。虽然只有8%的患者有严重的胃肠道受累，但这些患者的死亡率很高。最近的研究对疾病的病理生理学强调新的机制来解释胃肠动力障碍，但治疗仍然对症。本文综述了胃肠道的病理生理学，并讨论了疾病的调查和管理。
The gastrointestinal tract, affecting more than 90% of patients, is the internal organ most frequently involved in systemic sclerosis. Any part of the gastrointestinal tract can be affected, from the mouth to the anus. Patients often experience reduced quality of life and impaired social life. Although only 8% have severe gastrointestinal involvement, mortality is high in those patients. Recent studies on the pathophysiology of the disease highlight new mechanisms to explain gastrointestinal dysmotility, but treatment remains symptomatic. This article reviews the pathophysiology of the gastrointestinal tract and discusses the investigation and management of the disease.