Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis
Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis
复制标题
DOI：
10.1017/s0950268805003833
复制
发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Teunis, PFM
中科院分区：
文献类型：
--
作者：
Versteegh, FGA;Mertens, PLJM;Teunis, PFM
为了研究百日咳毒素IgG抗体（IgG-PT）自然感染后下降率与年龄的可能相关性，我们检测了121例患者（年龄0-94岁）在123次B发作后获得的随访血清中的IgG-PT。百日咳感染为了分析，我们应用了B失活的动态模型。百日咳免疫系统不同年龄组之间的IgG-PT上升、峰值和下降无显著差异，但随着年龄的增长，有上升更快、峰值更高和下降更快的趋势。百日咳血清学诊断的IgG-PT临界值100 U/ml在所有年龄组中均有效。IgG-PT下降至< 10 U/ml与B再感染风险增加相关。百日咳。
To investigate the possible dependence on age of the rate of decline of IgG antibodies to pertussis toxin (IgG-PT) after natural infection with Bordetella pertussis we measured IgG-PT in follow-up sera of 121 patients (age 0-94 years) obtained after 123 episodes of B. pertussis infection. For analysis we applied a dynamic model for the inactivation of B. pertussis by the immune system. There were no significant differences in rise, peak and decline of IgG-PT between different age groups, although there was a tendency for a more rapid increase, a higher peak and a faster decline with increasing age. The IgG-PT cut-off of 100 U/ml for serodiagnosis of pertussis appeared valid in all age groups. A decline of IgG-PT to < 10 U/ml was associated with increased risk of re-infection with B. pertussis.