In vivo biodistribution of ginkgolide B, a constituent of Ginkgo biloba, visualized by MicroPET.
In vivo biodistribution of ginkgolide B, a constituent of Ginkgo biloba, visualized by MicroPET.
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DOI：
10.1055/s-2005-871267
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发表时间：
2005-07
期刊：
影响因子：
2.7
通讯作者：
M. Suehiro;N. Simpson;M. Underwood;J. Castrillon;K. Nakanishi;R. V. Van Heertum
中科院分区：
文献类型：
--
作者：
M. Suehiro;N. Simpson;M. Underwood;J. Castrillon;K. Nakanishi;R. V. Van Heertum
银杏内酯B（GB）是银杏叶提取物的萜内酯成分，采用正电子发射断层扫描（PET）成像技术，用正电子发射体（18）F标记GB类似物，观察其在活体动物体内的动态行为。结合离体解剖实验的体内成像研究表明，GB在体内以2种形式存在：其内酯环闭合的原始GB和其中一个环打开的第二种形式。血浆中的原始GB被各种器官迅速吸收，包括肝脏、肠和可能的胃。因此，在等离子体中，GB的电离形式的比例随时间急剧增加。此后，两种形式之间的比例似乎缓慢地向平衡转变。结果表明，更多的注意力需要集中在体内动力学之间的2种形式的GB。
The in vivo dynamic behavior of ginkgolide B (GB), a terpene lactone constituent of the Ginkgo biloba extracts, in the living animal was visualized by positron emission tomographic (PET) imaging using a GB analogue labeled with the positron emitter (18)F. The in vivo imaging studies, combined with ex vivo dissection experiments, reveal that GB exists in 2 forms in the body: the original GB with its lactone rings closed and a second form with one of the rings open. The original GB in plasma is taken up rapidly by various organs including the liver, the intestine and possibly the stomach. Consequently, in plasma, the proportion of the ionized form of GB increases dramatically with time. Thereafter the ratio between the 2 forms appears to shift slowly towards equilibrium. The results suggest that more attention needs to be focused on in vivo dynamics between the 2 forms of GB.