Pleural fluid MDA and serum-effusion albumin gradient in pleural effusion
Pleural fluid MDA and serum-effusion albumin gradient in pleural effusion
复制标题
胸腔积液中的胸水 MDA 和血清白蛋白梯度
DOI：
10.1007/s12291-008-0019-1
复制
发表时间：
2008
影响因子：
2.1
通讯作者：
P. C. Mohapatra
中科院分区：
文献类型：
--
作者：
M. Mangaraj;S. Kumari;R. Nanda;M. Pattnaik;P. C. Mohapatra
对 60 名不同病因的胸腔积液患者的胸水丙二醛 (PMDA) 和血清积液白蛋白梯度 (SEAG) 进行了评估。将结果与 Light 的标准进行比较，以区分漏出液和渗出液。漏出液和渗出液中的平均 PMDA 水平分别为 0.68±0.24nmol/ml 和 1.17±0.25nmol/ml，显示与漏出液相比，渗出液有统计学显着性 (p<0.05) 上升。与漏出液相比，SEAG 发现渗出液显着下降 (P<0.001)。 PMDA与胸膜蛋白呈正相关（r=+0.30），与SEAG呈显着负相关（r=-0.33）。PMDA的敏感性和特异性均优于Light标准的参数。而 SEAG 记录的敏感性、特异性、阳性预测值 (PPV) 和阴性预测值 (NPV) 与 Light 的标准大致相同。因此，除 Light 标准外，还可以将 PMDA 和 SEAG 结合起来，以加强边缘性胸腔积液病例中漏出液和渗出液的区分。
Pleural fluid malondialdehyde (PMDA) and serum effusion albumin gradient(SEAG) were estimated in 60 patients of pleural effusion of diverse etiologies. The results were compared with Light’s criteria to distinguish between transudates and exudates. The mean PMDA level was 0.68±0.24nmol/ml and 1.17±0.25nmol/ml in transudates and exudates respectively showing a statistically significant (p<0.05) rise in exudates in comparison to transudates. SEAG registered a significant fall in exudates (P<0.001) when compared with transudates. PMDA revealed a positive correlation with pleural protein(r=+0.30) and a significant negative association with SEAG (r= −0.33).Sensitivity and specificity of PMDA were better than the parameters of Light’s criteria. Whereas SEAG documented approximately equal sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) with Light’s criteria. Therefore PMDA and SEAG can be taken together in addition to Light’s criteria to strengthen the discrimination between transudates and exudates in borderline cases of pleural effusion.