The role of optical coherence tomography angiography in fundus vascular abnormalities.
The role of optical coherence tomography angiography in fundus vascular abnormalities.
复制标题
光学相干断层扫描血管造影在眼底血管异常中的作用
DOI：
10.1186/s12886-016-0277-2
复制
发表时间：
2016-07-13
影响因子：
2
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Yu S;Lu J;Cao D;Liu R;Liu B;Li T;Luo Y;Lu L
目的探讨光学相干断层血管成像( )在眼底血管病变中的应用价值。方法对视网膜分支静脉阻塞、非增殖型糖尿病视网膜病变、增殖型糖尿病视网膜病变、渗出型老年性黄斑变性、息肉状脉络膜血管病变等眼底病变患者各10例进行眼底血管成像检查。进行OCTA成像和荧光素血管造影/吲哚青绿血管造影。在视网膜后方6 × 6 mm的扫描范围内，采用分裂谱幅度解相关血管成像算法进行血管成像。使用分割算法从任意层获得二维图像。分析OCTA表现，并与常规血管造影结果进行比较。结果OCTA能准确显示视网膜及脉络膜后部血管的正常和异常图像。OCTA能清晰显示黄斑缺血区扩大、视网膜无灌注区、微动脉瘤、视网膜新生血管、脉络膜新生血管、分支血管网、脉络膜息肉样病变等血管病变。结论OCTA能较好地显示视网膜后部及脉络膜血管病变，并能准确定位血管病变。非侵入性OCTA有助于诊断视网膜后部及脉络膜血管异常。
BackgroundTo evaluate the role of optical coherence tomography angiography (OCTA) in observation of fundus vascular abnormalities.MethodsPatients (n= 50, 10 in each group) with fundus disorders including branch retinal vein occlusion (BRVO), non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), exudative age-related macular degeneration (AMD), and polypoidal choroidal vasculopathy (PCV) were examined. They underwent imaging of OCTA and fluorescein angiography/indocyanine green angiography. The split-spectrum amplitude-decorrelation angiography algorithm was employed to obtain angiography within a 6 × 6 mm scanning area at the posterior retina. Segmentation algorithm was used to obtain 2-dimensional images from arbitrary layers. The OCTA features were analyzed and compared with the findings of conventional angiography. The contralateral eyes of the patients with BRVO and the eyes of 20 healthy volunteers served as controls.ResultsOCTA showed precise images of normal and abnormal vasculature in the posterior retina and choroid by the given layers. Vascular abnormalities such as enlarged foveal avascular zone (FAZ), non-perfusion area of retina, microaneurysm, retinal neovascularization, choroidal neovascularization (CNV), branching vascular network and polypoidal lesions in choroid were clearly displayed by OCTA.ConclusionsOCTA provided a better projection of vascular pathologies of the posterior retina and choroid and could determine the precise location of the vascular lesion. The noninvasive OCTA can benefit the diagnosis of vascular abnormalities in the posterior retina and choroid.