Eotaxin and impaired lung function in asthma
Eotaxin and impaired lung function in asthma
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DOI：
10.1164/ajrccm.160.6.9811089
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发表时间：
1999-12-01
影响因子：
24.7
通讯作者：
Lilly, CM
中科院分区：
文献类型：
--
作者：
Nakamura, H;Weiss, ST;Lilly, CM
我们在不同种族和地理位置分散的人群中进行了血浆eotaxin水平、嗜酸性粒细胞计数、总IgE水平、哮喘诊断和肺功能的相关性研究。我们研究了515名哮喘患者和519名正常受试者，他们都没有吸入或口服皮质类固醇。Logistic回归分析显示哮喘诊断与eotaxin水平有直接关系（p < 0.0001）。eotaxin组哮喘诊断的几率增加，与最低eotaxin组相比，最高四分位数的比值比为5.4 （95% CI 3.2 ~ 9.2, p < 0.001）。Eotaxin水平与肺功能呈负相关（p < 0.001），在Eotaxin最高的四分位数中，预测FEV1的平均百分比为13.5% （SEM为2.1,p < 0.001）低于最低的四分位数，血浆Eotaxin水平与哮喘相关，与肺功能呈负相关，与年龄、种族、性别或吸烟状况无关。当与嗜酸性粒细胞计数和IgE水平结合时，eotaxin水平有助于哮喘诊断和肺功能受损的几率。我们的研究结果是第一个将eotaxin杠杆与哮喘诊断和肺功能受损联系起来的研究。
We performed an association study of plasma eotaxin levels, eosinophil counts, total IgE levels, asthma diagnosis, and lung function in an ethnically diverse and geographically dispersed population. We studied 515 asthmatic and 519 normal subjects, none of whom was taking inhaled or oral corticosteroids. Logistic regression analysis demonstrated a direct relationship between asthma diagnosis and eotaxin levels (p < 0.0001). The odds of an asthma diagnosis increased with eotaxin quartile, with the highest quartile having an odds ratio of 5.4 (95% CI 3.2 to 9.2, p < 0.001) compared with the lowest eotaxin quartile. Eotaxin levels were inversely related to lung function (p < 0.001), with the mean percent predicted FEV1 in the highest eotaxin quartile being 13.5 percentage paints (SEM 2.1, p < 0.001) less than that in the lowest quartile, Plasma eotaxin levels were associated with asthma and inversely related to lung function independent of age, race, sex, or smoking status. When combined with eosinophil counts and IgE levels, eotaxin levels contributed to the odds of an asthma diagnosis and of impaired lung function. Our results are the first to associate eotaxin levers with asthma diagnosis and compromised lung function in a large geographically and ethnically diverse population.