Spatial constraints underlying the retinal mosaics of two types of horizontal cells in cat and macaque
Spatial constraints underlying the retinal mosaics of two types of horizontal cells in cat and macaque
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DOI：
10.1017/s0952523808080176
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发表时间：
2008-03-01
影响因子：
1.9
通讯作者：
Wong, James C. T.
中科院分区：
文献类型：
--
作者：
Eglen, Stephen J.;Wong, James C. T.
大多数类型的视网膜神经元在空间上以非随机模式定位，称为视网膜马赛克。一些发展机制被认为是重要的，在这些马赛克的形成。迄今为止的大多数证据表明，一种类型的神经元内的同型约束是占主导地位的，而不同类型的神经元之间的异型相互作用是罕见的。在对猕猴H1和H2水平细胞嵌合体的分析中，Wassle等人（2000年）提出，H1和H2嵌合体组合的高规则性指数可能是由发育期间的异型相互作用引起的。在这里，我们使用计算机建模表明，H1和H2组合马赛克的高规则性指数是两个神经元不能占据相同空间的基本约束的副产品。猫视网膜A型和B型水平细胞的空间排列也遵循同样的原则。
Most types of retinal neurons are spatially positioned in non-random patterns, termed retinal mosaics. Several developmental mechanisms are thought to be important in the formation of these mosaics. Most evidence to date suggests that homotypic constraints within a type of neuron are dominant, and that heterotypic interactions between different types of neuron are rare. In an analysis of macaque H1 and H2 horizontal cell mosaics, Wassle et al. (2000) suggested that the high regularity index of the combined H1 and H2 mosaic might be caused by heterotypic interactions during development. Here we use computer modeling to suggest that the high regularity index of the combined H1 and H2 mosaic is a by-product of the basic constraint that two neurons cannot occupy the same space. The spatial arrangement of type A and type B horizontal cells in cat retina also follow this same principle.