Biotransformation of some steroids by Mucor hiemalis MRC 70325
Biotransformation of some steroids by Mucor hiemalis MRC 70325
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DOI：
10.3184/174751913x13745069090242
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发表时间：
2013-09-01
影响因子：
1.4
通讯作者：
Kuru, Ali
中科院分区：
文献类型：
--
作者：
Yildirim, Kudret;Saran, Hilal;Kuru, Ali
In this work, incubations of testosterone, dehydroepiandrosterone and pregnenolone with Mucor hiemalis MRC 70325 have been reported. Incubation of testosterone afforded androst-4-en-3,17-dione (3%), 14 alpha-hydroxyandrost-4- en-3,17-dione (9%), 6 beta-hydroxyandrost-4-en-3,17-dione (2%) and 14 alpha, 17 beta-dihydroxyandrost-4-en-3-one (62%). Incubation of dehydroepiandrosterone afforded 3 beta, 17 beta-dihydroxyandrost-5-ene (6%) and 3 beta, 7 alpha-dihydroxyandrost-5-en- 17-one (72%). Incubation of pregnenolone afforded 3 beta, 14 alpha-dihydroxypregn-5-en-7,20-dione (3%), 3 beta, 7 alpha-dihydroxy-pregn-5-en-20-one (64%) and 3 beta, 7 alpha, 11 alpha-trihydroxypregn-5-en-20-one (11%). 3 beta, 14 alpha-Dihydroxypregn-5-en-7,20-dione was identified as a new metabolite.
