EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis.
EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis.
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DOI：
10.1136/annrheumdis-2011-200990
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发表时间：
2012-05
影响因子：
27.4
通讯作者：
Tak PP
中科院分区：
文献类型：
--
作者：
Gerlag DM;Raza K;van Baarsen LG;Brouwer E;Buckley CD;Burmester GR;Gabay C;Catrina AI;Cope AP;Cornelis F;Dahlqvist SR;Emery P;Eyre S;Finckh A;Gay S;Hazes JM;van der Helm-van Mil A;Huizinga TW;Klareskog L;Kvien TK;Lewis C;Machold KP;Rönnelid J;van Schaardenburg D;Schett G;Smolen JS;Thomas S;Worthington J;Tak PP
风湿性关节炎危险因素研究组由EULAR调查风湿学常务委员会成立，以促进对类风湿性关节炎（RA）临床前和最早临床表现阶段的研究。本报告描述了用于定义疾病不同阶段特定亚组的术语建议，并确定了该领域研究的优先事项。通过三阶段结构化过程讨论术语：将RA诊断前每个可能阶段的描述符临时列表分发给研究组成员进行审查和反馈。在为期两天的会议之前，将该名单上成员的匿名评论反馈给与会者。18名参与者开会讨论这些数据，商定术语并优先考虑重要的研究问题。研究小组建议，在前瞻性研究中，没有RA的个体被描述为具有：RA的遗传风险因素; RA的环境风险因素;与RA相关的全身性自身免疫;没有临床关节炎的症状;未分类的关节炎;可以以组合方式使用。建议在上述五点的任何/任何组合之前使用前缀“pre-RA with：”，但仅用于回顾性描述个体在已知已发生RA后所经历的阶段。提出了确定疾病发作日期的方法。此外，还提出了重要的研究领域，包括可能启动适应性免疫反应的其他组织的研究，以及确定RA发展、进展和关节外特征发展的其他风险因素和生物标志物。这些建议为描述RA发展前阶段的方法提供了指导，这将有助于研究人员之间的沟通和研究之间的比较。已经确定了一些研究问题，需要建立新的群组，并开发新的技术，从不同地点成像和收集材料。
The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR Standing Committee on Investigative Rheumatology to facilitate research into the preclinical and earliest clinically apparent phases of rheumatoid arthritis (RA). This report describes the recommendation for terminology to be used to define specific subgroups during different phases of disease, and defines the priorities for research in this area. Terminology was discussed by way of a three-stage structured process: A provisional list of descriptors for each of the possible phases preceding the diagnosis of RA were circulated to members of the study group for review and feedback. Anonymised comments from the members on this list were fed back to participants before a 2-day meeting. 18 participants met to discuss these data, agree terminologies and prioritise important research questions. The study group recommended that, in prospective studies, individuals without RA are described as having: genetic risk factors for RA; environmental risk factors for RA; systemic autoimmunity associated with RA; symptoms without clinical arthritis; unclassified arthritis; which may be used in a combinatorial manner. It was recommended that the prefix ‘pre-RA with:’ could be used before any/any combination of the five points above but only to describe retrospectively a phase that an individual had progressed through once it was known that they have developed RA. An approach to dating disease onset was recommended. In addition, important areas for research were proposed, including research of other tissues in which an adaptive immune response may be initiated, and the identification of additional risk factors and biomarkers for the development of RA, its progression and the development of extra-articular features. These recommendations provide guidance on approaches to describe phases before the development of RA that will facilitate communication between researchers and comparisons between studies. A number of research questions have been defined, requiring new cohorts to be established and new techniques to be developed to image and collect material from different sites.
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影响因子：
27.4
作者：
van de Stadt, Lotte A.;van der Horst, Ann R.;Hamann, Dorte
通讯作者：
Hamann, Dorte
影响因子：
--
作者：
Gent, Yoony Y. J.;Voskuyl, Alexandre E.;van der Laken, Conny J.
通讯作者：
van der Laken, Conny J.
影响因子：
27.4
作者：
Verstappen, S. M. M.;McCoy, M. J.;Symmons, D. P. M.
通讯作者：
Symmons, D. P. M.
影响因子：
27.4
作者：
Aletaha, Daniel;Neogi, Tuhina;Hawker, Gillian
通讯作者：
Hawker, Gillian
影响因子：
4.9
作者：
Berglin, E;Padyukov, L;Dahlqvist, SR
通讯作者：
Dahlqvist, SR