Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[j]fluoranthenes from Stromata of Annulohypoxylon viridistratum (Hypoxylaceae, Ascomycota)
Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[j]fluoranthenes from Stromata of Annulohypoxylon viridistratum (Hypoxylaceae, Ascomycota)
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DOI：
10.3390/biom10050805
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发表时间：
2020-05-01
期刊：
影响因子：
5.5
通讯作者：
Stadler, Marc
中科院分区：
文献类型：
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作者：
Becker, Kevin;Wessel, Anna-Charleen;Stadler, Marc
在我们从热带真菌中寻找新的生物活性代谢产物的过程中，我们使用化学分类学和分类学方法来预选感兴趣的材料。最近，三个以前未描述的苯并[j]荧蒽（1-3）与已知的衍生物truncatone A和C（4，5）分离自最近描述的物种Annulohypoxylon viridistectum收集在泰国的子座。通过光谱方法，包括核磁共振（NMR）光谱和高分辨率质谱（HR-MS），阐明了它们的化学结构。我们提议将这些新化合物命名为绿分布素A-C，它们在基于细胞的试验中表现出弱至中等的抗菌和细胞毒性活性。
During the course of our search for novel biologically active metabolites from tropical fungi, we are using chemotaxonomic and taxonomic methodology for the preselection of interesting materials. Recently, three previously undescribed benzo[j]fluoranthenes (1-3) together with the known derivatives truncatones A and C (4, 5) were isolated from the stromata of the recently described species Annulohypoxylon viridistratum collected in Thailand. Their chemical structures were elucidated by means of spectral methods, including nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). The new compounds, for which we propose the trivial names viridistratins A-C, exhibited weak-to-moderate antimicrobial and cytotoxic activities in cell-based assays.