Effects of scopolamine and nicotine on human rapid information processing performance
Effects of scopolamine and nicotine on human rapid information processing performance
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东莨菪碱和尼古丁对人体快速信息处理能力的影响
DOI：
10.1007/bf00427761
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发表时间：
2004
影响因子：
3.4
通讯作者：
D. Warburton
中科院分区：
文献类型：
--
作者：
K. Wesnes;D. Warburton
在第一个实验中，在快速信息处理任务的10分钟基线测试后，受试者接受安慰剂，甲基东莨菪碱1.2 mg，东莨菪碱0.6 mg或东莨菪碱1.2 mg的口服剂量，并在1小时后再次进行20分钟的任务。东莨菪碱1.2毫克后，正确的检测显着降低超过20分钟的时间内，而没有这样的递减在其他三个条件下观察到。在第二项实验中，使用类似的设计研究尼古丁0.5 mg、1.0 mg和1.5 mg以及安慰剂的作用，不同之处在于，由于尼古丁吸收更快，在基线后10分钟进行了药物后测试。尼古丁有助于防止在安慰剂条件下随着时间的推移而发生的检测下降和反应时间增加。这些发现表明，对中枢胆碱能通路具有相反作用的化合物对涉及快速信息处理的任务的性能产生相反的影响，并且与本实验室先前的发现一致。
In the first experiment, after a 10-min baseline test on a rapid information processing task, subjects received oral doses of either placebo, methscopolamine 1.2 mg, scopolamine 0.6 mg or scopolamine 1.2 mg, and 1 h later performed the task again for a 20-min period. Following scopolamine 1.2 mg, correct detections were significantly lower over the 20-min period, whereas no such decrement was observed in the other three conditions. In the second experiment a similar design was used to study the effects of nicotine 0.5 mg, 1.0 mg and 1.5 mg and placebo, except that post-drug testing was carried out 10 min after baseline due to the faster absorption of nicotine. Nicotine helped prevent both the decline in detections and the increase in reaction time which occurred over time in the placebo condition. These findings indicate that compounds with opposite effects on central cholinergic pathways produce opposite effects on the performance of a task involving rapid information processing, and are consistent with previous findings from this laboratory.