Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: Results from the WHO-CARDIAC Study
Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: Results from the WHO-CARDIAC Study
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DOI：
10.1291/hypres.24.453
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发表时间：
2001-07-01
影响因子：
5.4
通讯作者：
Nara, Y
中科院分区：
文献类型：
--
作者：
Yamori, Y;Liu, LJ;Nara, Y
牛磺酸（2-氨基乙磺酸）与缺血性心脏病（IHD）风险之间的关系引起了相当大的兴趣，但关于牛磺酸在世界各地人群中的分布信息很少。本研究旨在描述全球16个国家24个人群中牛磺酸排泄水平的差异及其与IHD死亡率的相关性。这是一项多中心横断面研究。在每个中心，从当地人群中随机选择100名48-56岁的男性和100名女性。使用氨基酸分析仪（Hitachi 835，lbaragi，Japan）测定24小时尿牛磺酸排泄量。使用直接标准法计算相关人群中的IHD校正死亡率。结果表明：（1）牛磺酸24小时排泄量的25%、50%和75%的分布在研究人群中表现出很大的差异。牛磺酸的中位值范围为191.6 μ mol/天（St John，加拿大）至2，180.6 μ mol/天（别府，日本）（男性）和127.5 μ mol/天（莫斯科，俄罗斯）至1，590.0 μ mol/天（别府，日本）（女性）。日本人群样本中牛磺酸的总体中位数最高，其次是中国样本（上海和台湾）。然而，欧洲人、北美人和海洋高加索人的牛磺酸中位数要低得多，法国和西班牙的样本除外。(b)在24个男性研究人群样本中，牛磺酸的中位数与年龄校正的IHD死亡率显著负相关（R（2）=0.42，p
There is considerable interest in the association between taurine (2-aminoethanesufonic acid) and risk of ischemic heart disease (IHD), but little information has been made available on the distribution of taurine in populations around the world. The present study aimed to describe the differences in taurine excretion levels and their associations with IHD mortality rates in 24 populations in 16 countries worldwide. This was a multicenter cross-sectional study. In each center, 100 men and 100 women aged 48-56 years were selected randomly from the local populations. Twenty-four hour urinary taurine excretion was measured using an amino acid analyzer (Hitachi 835, lbaragi, Japan). Age-adjusted IHD mortality rates in the relevant populations were calculated using the direct standard method. The results indicated that (a) percentiles 25%, 50% and 75% of the distributions of 24-h taurine excretion showed large variations in the study populations. Median values of taurine ranged from 191.6 mu mol/day (St John, Canada) to 2,180.6 mu mol/day (Beppu, Japan) in males, and from 127.5 mu mol/day (Moscow, Russia) to 1,590.0 mu mol/day (Beppu, Japan) in females. The highest overall median value of taurine was found in the Japanese population samples, followed by the Chinese samples (Shanghai and Taiwan). European, North American and oceanic Caucasians, however, had much lower median values of taurine, except in the cases of the samples from France and Spain. (b) Median values of taurine were significantly associated negatively with age-adjusted IHD mortality rates across the 24 study population samples in men (R(2)=0.42, p