Cardiac Action Potentials, Ion Channels, and Gap Junctions
Cardiac Action Potentials, Ion Channels, and Gap Junctions
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心脏动作电位、离子通道和间隙连接
DOI：
10.1007/978-1-4419-6658-2_3
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
H. Rijen
中科院分区：
文献类型：
--
作者：
J. D. Bakker;H. Rijen
心肌细胞膜中各种离子通道之间的相互作用负责心脏细胞的去极化和复极化，而由间隙连接蛋白介导的细胞-细胞偶联参与通过心脏的动作电位的传播。在这一章中，心脏细胞的动作电位的不同阶段进行了讨论，并赋予在这些阶段活跃的最重要的离子通道的作用和特点。在正常条件下的各种离子和间隙连接通道的表达的差异进行了说明。还讨论了离子和间隙连接通道的表达和分布，发生在心脏疾病的变化。最后，配体门控和拉伸激活离子通道的作用进行了简要说明。
Interplay between various ion channels in the membrane of cardiomyocytes is responsible for depolarization and repolarization of the heart cells, whereas cell-to-cell coupling, mediated by gap junction proteins, is involved in propagation of the action potential through the heart. In this chapter, the different phases of the action potential of heart cells are discussed and the role and characteristics of the most important ion channels that are active during these phases are conferred. Differences in the expression of the various ion and gap junction channels under normal conditions are described. Also discussed are changes in ion and gap junction channel expression and distribution that occur in cardiac disease. Finally, the role of ligand-gated and stretch-activated ion channels is addressed briefly.
瞬时外向钾电流激活剂概括了布鲁格达综合征的心电图表现。
影响因子：
10.8
作者：
Calloe K;Cordeiro JM;Di Diego JM;Hansen RS;Grunnet M;Olesen SP;Antzelevitch C
通讯作者：
Antzelevitch C
影响因子：
3.7
作者：
Kanno, S;Saffitz, JE
通讯作者：
Saffitz, JE