Microbiome in NAFLD and ALD.
Microbiome in NAFLD and ALD.
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DOI：
10.1002/cld.494
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发表时间：
2015-09-01
影响因子：
--
通讯作者：
McClain CJ
中科院分区：
文献类型：
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作者：
Kirpich IA;Parajuli D;McClain CJ
肠道微生物区系是一个复杂多样的生态系统，至少由1013到1014个微生物细胞组成。这种微生物组代表的遗传物质是人类基因组大小的100多倍，被称为“元基因组”。最先进的元基因组技术表明，最丰富的肠道细菌是杆菌门和细菌门的成员。1在过去的十年中，肠道微生物区系越来越被认为是非酒精性和酒精性脂肪性肝病(NAFLD和ALD)在啮齿动物和人类中的发病机制中的关键因素。本文对非酒精性脂肪肝和酒精性肝病的肠道微生物区系和相应的粪便代谢组学进行了简要概述。
The gut microbiota, a complex and diverse ecosystem, comprises at least 1013 to 1014 microbial cells. This microbiome represents genetic material more than 100 times the size of the human genome, and is called the ‘‘metagenome’’. State-of-the-art metagenomic technologies have revealed that the most abundant gut bacteria are members of the phyla Bacteroidetes and Firmicutes. 1 Over the past decade, the intestinal microbiota have increasingly been recognized as a critical factor in the pathogenesis of both nonalcoholic and alcoholic fatty liver disease (NAFLD and ALD, respectively) in rodents and humans. This article provides a brief overview of the gut microbiota and corresponding fecal metabolomics in NAFLD and ALD.