Chronic inflammation in mice exposed to the long-term un-entrainable light-dark cycles
Chronic inflammation in mice exposed to the long-term un-entrainable light-dark cycles
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暴露于长期不可控制的光暗循环的小鼠的慢性炎症
DOI：
10.1007/s41105-017-0127-5
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Yagita K.
中科院分区：
文献类型：
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作者：
Minami Y;Ohashi M;Hotta E;Hisatomi M;Okada N;Konishi E;Teramukai S;Inokawa H;Yagita K.
轮班工作在现代社会是必不可少的；因此，迫切需要采取措施维护轮班工人的健康。在这项前瞻性研究中，我们观察了不同类型的定时明暗转换条件对野生型小鼠的影响，我们将小鼠饲养在两种慢性时差条件下，分别是每7天8小时的相延迟（延迟，n= 14）和每4天8小时的相提前（n= 34），持续630天。“延迟”代表轻微的条件，小鼠被携带，而“提前”代表昼夜节律紊乱的条件，小鼠没有被携带。结果显示，在“提前”转移条件下，26.5%（9/34）的小鼠在整个实验过程中死亡或以人道终点处死，而在“延迟”转移条件下，第一次死亡发生在第611天。“提前”组小鼠的死亡率高于“延迟”组小鼠[HR (95% CI) 4.26(0.54 ~ 33.6)]。在寿命较短的“Advance”小鼠中，表现为脾肿大，骨髓中骨髓细胞增多，表明这些小鼠存在慢性炎症。虽然这项研究仍处于初步阶段，但这些发现表明，长期严重的昼夜节律紊乱可能导致慢性炎症的诱发，并往往导致寿命缩短。需要进一步的研究来了解昼夜节律紊乱为什么以及如何增加各种生理功能障碍和疾病的风险。
Shift work is indispensable in our modern society; therefore, measures for maintaining the health of shift workers are urgently required. In this prospective study observing the effects of different types of scheduled light–dark shift conditions in wild-type mice, we reared mice for 630 days under two chronic jet lag conditions with distinct programs of light and darkness: an 8-h phase delay every 7 days (delay,n= 14) or an 8-h phase advance every 4 days (advance,n= 34). “Delay” represents a mild condition in which mice are entrained, whereas “Advance” represents a condition of circadian rhythm disorder in which mice are not entrained. Our results showed that the 26.5% (9/34) mice reared under the “Advance” shift condition died or were sacrificed by humane endpoint throughout the experiment, whereas the first death under “Delay” condition occurred on day 611. The mortality rate of the mice reared under “Advance” condition was higher than the mice under “Delay” condition [HR (95% CI) 4.26 (0.54–33.6)]. In “Advance” mice of shorter lifespan, which showed splenomegaly and increased myeloid cells in bone marrow, which indicates that chronic inflammation existed in those mice. Although this study is still preliminary, these findings suggest that prolonged severe circadian rhythm disorder may result in the induction of chronic inflammation and tend to result in a shorter lifespan. Further studies are needed to understand why and how circadian rhythm disorder increases the risk of various dysfunction of physiology and diseases.