Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group
Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group
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DOI：
10.1200/jco.2011.37.8018
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发表时间：
2012-05-10
影响因子：
45.3
通讯作者：
Carroll, William L.
中科院分区：
文献类型：
--
作者：
Hunger, Stephen P.;Lu, Xiaomin;Carroll, William L.
目的检查 1990 年至 2005 年间参加儿童肿瘤学组 (COG) 临床试验的急性淋巴细胞白血病 (ALL) 儿童和青少年的基于人群的生存改善以及临床协变量对结果的影响。 患者和方法 1990 年至 2005 年期间，共有 21,626 名 0 至 22 岁的人参加了 COG ALL 临床试验，代表在此期间，估计 55.8% 的 ALL 病例发生在 20 岁以下的美国人中。这一时期被分为三个时期（1990-1994 年、1995-1999 年和 2000-2005 年），其中包括相似的患者数量，以检查 5 年和 10 年生存率随时间的变化以及这些生存率变化与临床协变量的关系，并对死亡原因进行额外分析。结果五年生存率从 1990-1994 年的 83.7% 增加到2000-2005 年为 90.4% (P < .001)。所有亚组的生存率均显着提高（婴儿年龄除外）
PurposeTo examine population-based improvements in survival and the impact of clinical covariates on outcome among children and adolescents with acute lymphoblastic leukemia (ALL) enrolled onto Children's Oncology Group (COG) clinical trials between 1990 and 2005.Patients and MethodsIn total, 21,626 persons age 0 to 22 years were enrolled onto COG ALL clinical trials from 1990 to 2005, representing 55.8% of ALL cases estimated to occur among US persons younger than age 20 years during this period. This period was divided into three eras (1990-1994, 1995-1999, and 2000-2005) that included similar patient numbers to examine changes in 5- and 10-year survival over time and the relationship of those changes in survival to clinical covariates, with additional analyses of cause of death.ResultsFive-year survival rates increased from 83.7% in 1990-1994 to 90.4% in 2000-2005 (P < .001). Survival improved significantly in all subgroups (except for infants age