Anti-influenza A virus activities of mannan-binding lectins and bovine conglutinin
Anti-influenza A virus activities of mannan-binding lectins and bovine conglutinin
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DOI：
10.1292/jvms.69.221
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发表时间：
2007-02-01
影响因子：
1.2
通讯作者：
Wakamiya, Nobutaka
中科院分区：
文献类型：
--
作者：
Kawai, Takao;Kase, Tetsuo;Wakamiya, Nobutaka
甘露聚糖结合凝集素 (MBL) 和牛球凝素 (BKg) 属于集合素家族，参与宿主针对各种感染因子的一线防御。我们之前曾报道，人 MBL 可以抑制甲型流感病毒血凝、感染和扩散到邻近细胞，而无需补体激活。在本研究中，我们研究了牛 MBL、兔 MBL 和 BKg 的直接抗病毒活性。本研究中使用的所有集合素在浓度为 0.02-0.3 μg/ml 时均能抑制病毒感染性和血凝作用。它们还表现出对病毒传播的抑制活性。与人 MBL 一样，牛 MBL 和 BKg 在其生理浓度下也显示出抗病毒活性。这些结果表明哺乳动物 MBL 和 BKg 可能抑制甲型流感病毒通过血流的传播。
Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 mu g/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.