Tumor growth dynamics: insights into evolutionary processes
Tumor growth dynamics: insights into evolutionary processes
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DOI：
10.1016/j.tree.2013.05.020
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发表时间：
2013-10-01
影响因子：
16.8
通讯作者：
Wodarz, Dominik
中科院分区：
文献类型：
--
作者：
Rodriguez-Brenes, Ignacio A.;Komarova, Natalia L.;Wodarz, Dominik
识别驱动肿瘤演变和进展的事件类型对于理解癌症至关重要。我们认为，对肿瘤生长动力学的分析可以通过将它们与发生的遗传变化类型联系起来，为肿瘤生物学和进化提供一个窗口。虽然从根本上重要的是，文献中的肿瘤生长动力学的文件是更稀疏比细胞的分子分析。在这里，我们提供了肿瘤生长模式的历史总结，并认为它们可以分为五个基本类别。然后，我们通过讨论一个特定的进化模型作为例子，并鼓励在更一般的环境中进行这种分析，来说明这些类别如何为推动肿瘤进展的事件提供见解。
Identifying the types of event that drive tumor evolution and progression is crucial for understanding cancer. We suggest that the analysis of tumor growth dynamics can provide a window into tumor biology and evolution by connecting them with the types of genetic change that have occurred. Although fundamentally important, the documentation of tumor growth kinetics is more sparse in the literature than is the molecular analysis of cells. Here, we provide a historical summary of tumor growth patterns and argue that they can be classified into five basic categories. We then illustrate how those categories can provide insights into events that drive tumor progression, by discussing a particular evolutionary model as an example and encouraging such analysis in a more general setting.