Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.
Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.
复制标题
甲氨蝶呤治疗类风湿性关节炎期间发生原发性皮肤 B 细胞淋巴瘤。
DOI：
10.1016/0002-9343(85)90241-4
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
K. Imrie
中科院分区：
文献类型：
--
作者：
A. Fam;B. Perez–Ordoñez;K. Imrie
类风湿性关节炎患者在长期甲氨蝶呤（MTX）治疗期间发生可逆性原发性皮肤大B细胞淋巴瘤。停药后皮损消退提示与MTX密切相关。在这种罕见的淋巴组织增生性疾病的初始管理中，提高临床意识、停用MTX和密切观察是重要的。
A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.