Population exposure to a novel influenza A virus over three waves of infection
Population exposure to a novel influenza A virus over three waves of infection
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DOI：
10.1016/j.jcv.2011.08.019
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发表时间：
2011-12-01
影响因子：
8.8
通讯作者：
Carman, W. F.
中科院分区：
文献类型：
--
作者：
Adamson, W. E.;McGregor, E. C.;Carman, W. F.
背景：甲型H1N1流感病毒自2009年4月以来在全球蔓延。从那时起，已经进行了几项研究，以测量对该病毒起反应的抗体的频率。这些分析通常使用中和试验，并且通常采用>= 40的滴度来代表抗体的显著水平（该显著性源自其为试验可以检测的抗体的最低水平的四倍，而不是建立的保护相关性）。然而，与预防甲型H1N1流感相关的微量中和滴度尚未建立。目的：分析苏格兰多个时间点、不同年龄组和地理位置的甲型H1N1流感2009抗体血清阳性率，并全面描述苏格兰病毒的传播（与先前公布的数据一起）。这项研究首次提出了一种新的流感病毒对一个从未感染过的人群的影响，该人群从最初的爆发一直跟踪到大多数人群都有反应性抗体的时候。在该滴度下检测血液样本（2009年4月和2010年4月在爱丁堡（每年n = 400）以及2011年2月在阿伯丁、爱丁堡、格拉斯哥和因弗内斯（n = 1600）采集）是否存在甲型H1N1流感2009抗体。结果：在2010/2011年流感季节之后，有证据表明，大约五分之四的苏格兰人口曾接触过甲型H1N1流感病毒。结论：这项研究为进一步研究建立流感感染易感性和临床发展的可靠相关性提供了动力。疾病，为未来的疫情提供有用的信息，并与规划未来流感季节的公共卫生政策有关。(C)2011 Elsevier B. V.保留所有权利。
Background: The influenza A(H1N1)2009 virus has been spreading throughout the world since April 2009. Since then, several studies have been undertaken to measure the frequency of antibodies that react against the virus. Microneutralisation assays have regularly been used for these analyses, and titres of >= 40 have conventionally been taken to represent significant levels of antibodies (this significance is derived from it being four times the minimum level of antibodies that the assay can detect rather an established correlate of protection). However a microneutralisation titre that correlates with protection against influenza A(H1N1) 2009 has not been established.Objectives: Analysing influenza A(H1N1) 2009 antibody seroprevalence in Scotland at multiple timepoints, and in different age groups and geographical locations, and comprehensively describing the spread of the virus in Scotland (taken alongside previously published data). This study presents for the first time the effects of a novel influenza virus on a naive population that has been followed from the initial outbreak to a time when the majority of the population have reactive antibodies.Study design: A microneutralisation titre >= 10 represents the minimum level of antibodies detectable by the assay. Blood samples (taken in April 2009 and April 2010 in Edinburgh (n = 400 each year), and in February 2011 in Aberdeen, Edinburgh, Glasgow, and Inverness (n = 1600)) were tested for the presence of influenza A(H1N1) 2009 antibodies at this titre. This represents an effective indicator of the proportion of a population who have been exposed to the virus.Results: Following the 2010/2011 influenza season, there is evidence of exposure to influenza A(H1N1) 2009 in approximately four fifths of the Scottish population.Conclusions: This study provides impetus to the call for further research in establishing robust correlates of susceptibility to influenza infection and the development of clinical illness, provides useful information for future outbreaks, and is relevant to public health policy in planning for future influenza seasons. (C) 2011 Elsevier B.V. All rights reserved.