Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging
Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging
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DOI：
10.1016/j.neuroimage.2007.02.023
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发表时间：
2007-05-01
期刊：
影响因子：
5.7
通讯作者：
Henkelman, R. Mark
中科院分区：
文献类型：
--
作者：
Spring, Shoshana;Lerch, Jason P.;Henkelman, R. Mark
在包括人类在内的许多脊椎动物物种的大脑中，已经描述了大量的性二型。自然发生的两性异形与许多神经系统疾病的风险、进展和恢复有关，包括头部损伤、多发性硬化和中风。转基因小鼠是研究哺乳动物中枢神经系统结构-功能关系的重要工具，也是人类神经精神和神经系统疾病的模型。然而，成年小鼠大脑结构的定量三维分析数量有限。为了解决我们对解剖学差异的认识的局限性，使用全3D磁共振成像（MRI）进行了一项全面的研究，以检查C57 BL/6 J小鼠全脑的性二态性。两性之间的整体大脑大小存在预期差异，男性大脑的体积比女性大脑大2.5%。除了性别之间的总体脑大小差异外，还发现以下显著不同的区域：男性在丘脑、初级运动皮层和后海马区较大，而女性在下丘脑后区、内嗅皮层和前海马区较大。使用高清晰度3D MRI对正常近交系小鼠品系，我们已经详细绘制了许多与性别相关的脑结构统计学显著差异。(c)2007爱思唯尔公司All rights reserved.
A large variety of sexual dimorphisms have been described in the brains of many vertebrate species, including humans. Naturally occurring sexual dimorphism has been implicated in the risk, progression and recovery from numerous neurological disorders, including head injury, multiple sclerosis and stroke. Genetically altered mice are a key tool in the study of structure-function relationships in the mammalian central nervous system and serve as models for human neuropsychiatric and neurological disorders . However, there are a limited number of quantitative three-dimensional analyses of the adult mouse brain structures. In order to address limitations in our knowledge of anatomical differences, a comprehensive study was undertaken using full 3D magnetic resonance imaging (MRI) to examine sexual dimorphisms in the C57BL/6J whole mouse brain. An expected difference in overall brain size between the sexes was found, where male brains were 2.5% larger in volume than female brains. Beyond the overall brain size differences in the sexes, the following significantly different regions were found: males were larger in the thalamus, primary motor cortex and posterior hippocampus, while females were larger in posterior hypothalamic area, entorhinal cortex and anterior hippocampus. Using high-definition 3D MRI on a normal inbred mouse strain, we have mapped in detail many sex-associated statistically significant differences in brain structures. (c) 2007 Elsevier Inc. All rights reserved.