INHIBITION OF BACTERIAL ADHERENCE BY NASOPHARYNGEAL SECRETIONS
INHIBITION OF BACTERIAL ADHERENCE BY NASOPHARYNGEAL SECRETIONS
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DOI：
10.1177/000348949110000605
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发表时间：
1991-06-01
影响因子：
1.4
通讯作者：
MOGI, G
中科院分区：
文献类型：
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作者：
KURONO, Y;SHIGEMI, H;MOGI, G
体外研究鼻咽分泌物中分泌型免疫球蛋白(Ig)A在肺炎链球菌和流感嗜血杆菌与鼻咽上皮细胞黏附中的作用。用鼻咽分泌物处理细菌可显著降低粘附率，具有分泌型抗细菌IgA抗体活性的鼻咽分泌物的抗粘附性明显强于无活性的鼻咽液。鼻咽分泌物中的免疫球蛋白被吸收后，其抗黏附活性无明显变化。结果提示，鼻咽分泌物中的分泌型IgA与细菌黏附有关，有助于预防鼻咽部感染。
The role of secretory immunoglobulin (Ig) A in nasopharyngeal secretions in the adherence of Streptococcus pneumoniae and Hemophilus influenzae to nasopharyngeal epithelial cells was investigated in vitro. The adherence was remarkably reduced by treating bacteria with nasopharyngeal secretions, and the antiadhesive activity was significantly greater in nasopharyngeal secretions having secretory IgA antibody activity against bacteria than in those having no activity. Noticeable changes were not observed in the antiadhesive activity caused by absorption of IgG from nasopharyngeal secretions. Results suggest that secretory IgA in nasopharyngeal secretions is related to bacterial adherence and adds to the prevention of nasopharyngeal infections.