Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese.
Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese.
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DOI：
10.2188/jea.je20140250
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发表时间：
2015
影响因子：
4.7
通讯作者：
Shinkai S
中科院分区：
文献类型：
--
作者：
Taniguchi Y;Fujiwara Y;Nofuji Y;Nishi M;Murayama H;Seino S;Tajima R;Matsuyama Y;Shinkai S
臂踝脉搏波速度（baPWV）与认知功能呈负相关。然而，目前尚不清楚baPWV是否能预测晚年的认知能力下降（CD）。我们研究了在日本老年人群中baPWV是否是随后CD的独立风险标志物。在参与基线调查的982名年龄在65岁或以上的成年人中，526名认知完整的成年人（简易精神状态检查[MMSE]评分≥24;平均[SD]年龄，71.7 [5.6]岁;女性，57.8%）被随访长达5年。使用自动波形分析仪测定脉搏波速度。认知功能通过MMSE进行评估，CD定义为MMSE评分下降2分或2分以上。在平均3.4年的随访期间，85名参与者（16.2%）发展为CD。在控制了重要的混杂因素后，baPWV最高和中间三分位数与最低三分位数相比，CD的比值比分别为2.95（95%置信区间，1.29-6.74）和2.39（95%置信区间，1.11-5.15）。高baPWV是一般老年人群中CD的独立预测因子，可能有助于老年人的临床评价。
Brachial-ankle pulse wave velocity (baPWV) is inversely associated with cognitive function. However, it is not known whether baPWV predicts cognitive decline (CD) in later life. We examined whether or not baPWV is an independent risk marker of subsequent CD in a population of older Japanese. Among 982 adults aged 65 years or older who participated in a baseline survey, 526 cognitively intact adults (Mini-Mental State Examination [MMSE] score ≥24; mean [SD] age, 71.7 [5.6] years; women, 57.8%) were followed for a period of up to 5 years. Pulse wave velocity was determined using an automated waveform analyser. Cognition was assessed by the MMSE, and CD was defined as a decrease of two points or more on the MMSE. During an average follow-up of 3.4 years, 85 participants (16.2%) developed CD. After controlling for important confounders, the odds ratios for CD in the highest and middle tertiles of baPWV, as compared with the lowest tertile, were 2.95 (95% confidence interval, 1.29–6.74) and 2.39 (95% confidence interval, 1.11–5.15), respectively. High baPWV was an independent predictor of CD in a general population of older adults and may be useful in the clinical evaluation of elders.