Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis.
Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis.
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DOI：
10.1186/s10194-016-0693-y
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Pierelli F
中科院分区：
文献类型：
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作者：
Coppola G;Di Renzo A;Tinelli E;Lepre C;Di Lorenzo C;Di Lorenzo G;Scapeccia M;Parisi V;Serrao M;Colonnese C;Schoenen J;Pierelli F
静息状态磁共振成像允许研究功能互联的大脑网络。在此，我们旨在验证无先兆偏头痛（MO）患者在发作之间休息时脑网络之间的功能连通性及其与丘脑微观结构的关系。18名未经治疗的MO患者接受了3t MRI扫描，并与19名健康志愿者（HV）进行了比较。我们使用MRI收集两个选定的静息状态网络的静息状态数据，使用组独立成分（IC）分析进行识别。双侧丘脑的分数各向异性（FA）和平均扩散率（MD）值来自先前对同一受试者的扩散张量成像研究，并与静息状态ic z分数相关。与HV相比，在MO中，我们发现默认模式网络和视觉空间系统之间的功能连通性显著降低。HV和偏头痛患者选择的ic z得分与双侧丘脑FA值呈负相关。目前的结果是支持以下假设的第一个证据，即与基线丘脑微观结构显著差异相关的网络连接异常休息可能有助于偏头痛的病理生理。
Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients between attacks. Eighteen patients with untreated MO underwent 3 T MRI scans and were compared to a group of 19 healthy volunteers (HV). We used MRI to collect resting state data among two selected resting state networks, identified using group independent component (IC) analysis. Fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from a previous diffusion tensor imaging study on the same subjects and correlated with resting state ICs Z-scores. In comparison to HV, in MO we found significant reduced functional connectivity between the default mode network and the visuo-spatial system. Both HV and migraine patients selected ICs Z-scores correlated negatively with FA values of the thalamus bilaterally. The present results are the first evidence supporting the hypothesis that an abnormal resting within networks connectivity associated with significant differences in baseline thalamic microstructure could contribute to interictal migraine pathophysiology.