Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
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DOI：
10.1039/c8na00191
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发表时间：
2019-02-01
影响因子：
4.7
通讯作者：
Gu, Zhongwei
中科院分区：
文献类型：
--
作者：
Jiang, Qian;Chen, Xiaobing;Gu, Zhongwei
将多肽-喜树碱前药(RSC)系统设计为纳米级多级火箭，在肿瘤相关还原和酯酶强化的条件下，有效地络合和控制siRNA和抗癌药物的顺序释放，从而避免了负相互作用，最大限度地发挥了协同作用。
An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.