Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders
Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders
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DOI：
10.1016/s0266-4356(02)00215-2
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发表时间：
2002-10-01
影响因子：
1.8
通讯作者：
Sato, J
中科院分区：
文献类型：
--
作者：
Kaneyama, K;Segami, N;Sato, J
用双抗体夹心ELISA法测定了117例颞下颌关节紊乱病(TMD)患者关节滑液中细胞因子的浓度，并与临床症状及退行性改变进行了相关分析。7名健康志愿者的体液作为对照。关节液中IL-1β、肿瘤坏死因子-α、IL-6、IL-8浓度均显著高于对照组(P<0.05)。退行性变患者的IL-6浓度显著高于其他患者(P<；0.05)。IL-8的检测与IL-6、TNF-α的浓度呈正相关。滑液中的细胞因子可能参与了TMD的发病过程。尤其是IL-6很重要，可能与骨性关节炎的发生发展有关。(C)2002年英国口腔和颌面外科医生协会。爱思唯尔科学有限公司出版。版权所有。
The concentrations of cytokines were measured by an ELISA in the synovial fluid from 117 patients with temporomandibular disorders (TMD) and correlated with degenerative changes of the condyle and clinical symptoms.Fifty-seven patients had degenerative changes of the condyle. The fluid from seven healthy volunteers was used as controls. The concentrations of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly higher in the synovial fluid of patients than controls (P < 0.05). The concentration of IL-6 was significantly higher in the patients with degenerative changes than in other patients (P < 0.05). The detection of IL-8 correlated with the concentrations of IL-6 and TNF-alpha. However, there was no correlation between the concentrations of any cytokines and symptoms.In conclusion, the cytokines in the synovial fluid may participate in the pathogenesis of TMD. In particular, IL-6 is important and may be associated with the development of osteoarthritis. (C) 2002 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Science Ltd. All rights reserved.