RECOMBINATION OF HUMAN INFLUENZA-A VIRUSES IN NATURE
RECOMBINATION OF HUMAN INFLUENZA-A VIRUSES IN NATURE
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DOI：
10.1038/284638a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
KENDAL, AP
中科院分区：
文献类型：
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作者：
BEAN, WJ;COX, NJ;KENDAL, AP
1977年，流感流行病学发生了一个独特的事件，当时一种类似于1950年发生的甲型H1N1流感亚型的病毒重新出现，引起了全球流行，但没有取代流行的甲型H3N1亚型1-6。因此，这两种病毒在世界各地共同传播1，7并发现一些人同时感染两种病毒株8，9，这增加了两种病毒株之间的重组可能影响未来流感流行病学行为的可能性。然而，对1978-79年冬季流感暴发的病毒分离株进行血清学分析，没有检测到任何抗原性杂交(H3N1或H1N2)。因此，这里描述的调查是为了在最近分离的H1N1和H3N1血清型中检测重组体，涉及通过RNA-RNA杂交法编码表面蛋白以外的基因。我们在这里报告了这两种抗原类型重组体的基因特征。
In 1977, a unique event occurred in the epidemiology of influenza when a virus of the influenza A (H1N1) subtype, similar to a virus that had occurred in 1950, reappeared and caused worldwide epidemics but did not replace the prevailing influenza A (H3N2) subtype1–6. Consequently, the two viruses co-circulated throughout the world1,7arid mixed infection of some individuals with both virus strains was detected8,9, raising the possibility that recombination between the two strains might affect the future epidemiological behaviour of influenza. Serological analysis of virus isolates from influenza outbreaks during the winter of 1978–79, however, failed to detect any antigenic hybrids (H3N1 or H1N2). The investigation described here, was therefore, undertaken to detect recombinants among recent isolates of the H1N1 and H3N2 serotypes, involving genes coding for other than the surface proteins by RNA–RNA hybridisation. We report here the genetic characterisation of recombinants of both antigenic types.