GROWTH AND DEVELOPMENT OF BRAIN AND SPINAL CORD OF GUINEA PIG
GROWTH AND DEVELOPMENT OF BRAIN AND SPINAL CORD OF GUINEA PIG
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DOI：
10.1016/0006-8993(70)90311-2
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发表时间：
1970-01-01
期刊：
影响因子：
2.9
通讯作者：
SANDS, J
中科院分区：
文献类型：
--
作者：
DOBBING, J;SANDS, J
研究了豚鼠从胎龄29天至成熟的脑和脊髓的生长和发育。通过测定组织结构某些化学指标的变化水平，试图定量描述细胞增殖和髓鞘形成的程度。通过这种方法，可以区分胶质细胞增殖和髓鞘形成的单独高峰期，这两个高峰期都发生在湿重增长最快的时期之后。这种描述大脑发育的方法是研究大脑在最快发育时期的高度脆弱性的第一步。这项研究还说明了大脑发育优先于身体其他部位的生长，髓鞘形成过程中脑水的流失，以及即使在细胞总数上升的时候细胞密度也会下降。所有这些与出生有关的事件发生的时间与该物种中枢神经系统发育的早熟性一致。
The growth and development of the brain and spinal cord of the guinea pig has been studied from 29 days of foetal life until maturity. An attempt has been made to describe cell multiplication and degree of myelination in quantitative terms by determining the changing levels of certain chemical indices of histological structure. By this means it has been posssible to distinguish separate peak periods of glial multiplication and myelination both of which occur later than the period of fastest growth in wet weight. This method of describing brain development was undertaken as a preliminary step in an investigation of the heightened vulnerability of the growing brain during its periods of fastest growth. The study has also illustrated the precedence taken by the developing brain over the growth of the rest of the body, the loss of brain water as myelination proceeds, and a falling cell density even at a time when the total number of cells is rising. The timing of all these events in relation to birth is in accordance with the precocity of central nervous system development in this species.