Dose-dependency in pleiotropic effects of atorvastatin
Dose-dependency in pleiotropic effects of atorvastatin
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DOI：
10.1055/s-0031-1278256
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发表时间：
2007-09-01
影响因子：
0.6
通讯作者：
Miwa, Kunihisa
中科院分区：
文献类型：
--
作者：
Fujita, Masatoshi;Morimoto, Tatsuya;Miwa, Kunihisa
他汀类药物被认为是降低血清胆固醇水平的主要和最有效的药物，因此显著减少心血管事件和死亡率。除了降脂外，他汀类药物还可能有一系列有益的生物学效应，这种现象通常被称为“多效性效应”。然而，这些效应的剂量依赖性仍不清楚。本研究评估了阿托伐他汀，一种有效的他汀类药物，是否改善了多效性效应的血清标志物，重点是剂量依赖关系。在一项前瞻性、随机、开放、交叉、单中心研究中，对15例原发性高胆固醇血症患者应用阿托伐他汀5 mg/d和10 mg/d治疗6个月的多效性进行了评估。阿托伐他汀治疗可剂量依赖性地降低氧化应激的血清标志物以及血清低密度脂蛋白胆固醇水平。然而，炎症和纤溶的血清标志物降低与剂量无关。综上所述，阿托伐他汀的多效性效应的剂量依赖性在不同的生物效应中是不同的。
Statins are recognized as the principal and most effective class of drugs for reducing serum cholesterol levels and, therefore, significantly reducing cardiovascular events and mortality. Statins may have a wide range of beneficial biological effects in addition to lipid lowering, a phenomenon commonly termed a 'pleiotropic effect'. However, the dose-dependency of these effects remains unclear. The present study evaluated whether atorvastatin, a potent statin, ameliorates the serum markers of pleiotropic effects, with a focus on dose-dependency. The pleiotropic effects of treatment with atorvastatin 5 mg/day and 10 mg/day for six months each in 15 patients with primary hypercholesterolemia were assessed in a prospective, randomized, open-label, crossover, single-centre study. Atorvastatin treatment dose-dependently decreased a serum marker of oxidative stress as well as the serum low- density lipoprotein cholesterol level. However, serum markers of inflammation and fibrinolysis decreased independently of dose. In conclusion, the dose-dependency of atorvastatin's pleiotropic effects differs among individual biological effects.