Broad Spectrum Microbicidal Activity of Photocatalysis by TiO2
Broad Spectrum Microbicidal Activity of Photocatalysis by TiO2
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DOI：
10.3390/catal3010310
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发表时间：
2013-03-01
期刊：
影响因子：
3.9
通讯作者：
Kubota, Yoshinobu
中科院分区：
文献类型：
--
作者：
Nakano, Ryuichi;Hara, Masayuki;Kubota, Yoshinobu
光催化活性二氧化钛（TiO2）作为一种自清洁和自消毒材料被广泛应用于许多领域，以保持环境的生物清洁。关于光催化反应灭活细菌和病毒的研究也有报道；然而，很少有研究评价光催化对不同物种的杀微生物活性谱。有必要确认光催化消毒对多重耐药细菌和病毒的预期有效性。在本研究中，通过比较将不同种类的细菌和病毒的悬浮液滴在二氧化钛镀膜玻璃表面时的失活情况，来评价光催化的杀微生物活性。革兰氏阳性菌如耐甲氧西林金黄色葡萄球菌、耐万古霉素粪肠球菌、耐青霉素肺炎链球菌等易被光催化灭活，而革兰氏阴性菌如大肠杆菌、耐多药铜绿假单胞菌等则逐渐被光催化灭活。与非包膜病毒猫杯状病毒相比，流感病毒（一种包膜病毒）在光催化作用下明显失活。光催化杀菌活性的有效性可能取决于表面结构。然而，在二氧化钛镀膜玻璃表面的光催化作用下，它们被有效地灭活。我们的数据强调，有效的清洁和消毒的光催化在医院设置防止病原体传播。
Photocatalytically active titanium dioxide (TiO2) is widely used as a self-cleaning and self-disinfecting material in many applications to keep environments biologically clean. Several studies on the inactivation of bacteria and viruses by photocatalytic reactions have also been reported; however, only few studies evaluated the spectrum of the microbicidal activity with photocatalysis for various species. There is a need to confirm the expected effectiveness of disinfection by photocatalysis against multidrug-resistant bacteria and viruses. In this study, microbicidal activity of photocatalysis was evaluated by comparing the inactivation of various species of bacteria and viruses when their suspensions were dropped on the surface of TiO2-coated glass. Gram-positive bacteria, e. g., methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae, were easily inactivated by photocatalysis, whereas some gram-negative bacteria, e. g., Escherichia coli and multidrug-resistant Pseudomonas aeruginosa, were gradually inactivated by photocatalysis. Influenza virus, an enveloped virus, was significantly inactivated by photocatalysis compared with feline calicivirus, a non-enveloped virus. The effectiveness of microbicidal activity by photocatalysis may depend on the surface structure. However, they are effectively inactivated by photocatalysis on the surface of TiO2-coated glass. Our data emphasize that effective cleaning and disinfection by photocatalysis in nosocomial settings prevents pathogen transmission.