Expression of estrogen receptor-α and β mRNA in the developing and adult mouse striatum
Expression of estrogen receptor-α and β mRNA in the developing and adult mouse striatum
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DOI：
10.1016/s0304-3940(99)00815-0
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发表时间：
1999-12-03
影响因子：
2.5
通讯作者：
Beyer, C
中科院分区：
文献类型：
--
作者：
Küppers, E;Beyer, C
雌激素不仅调节黑质纹状体的功能，而且还调节纹状体的发育过程。最近，我们已经证明了雌激素合成酶芳香化酶在发育中的小鼠纹状体的存在。本研究采用半定量逆转录-聚合酶链反应（RT-PCR）技术，对发育和成年小鼠纹状体雌激素受体-α/β（ER）mRNA的表达进行了研究。这两种ER亚型的表达在产前就已发生，并在出生前进一步增加。出生后早期，ER-α/β水平仍然很高，但在成人中降至较低水平。ER表达无性别差异。这些数据与我们以前的研究结果一起证明了在小鼠纹状体中ER亚型和芳香化酶的同时表达。它的结论是，雌激素信号通过两个核受体纹状体分化发挥了潜在的作用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Estrogen not only modulates nigrostriatal function but also developmental processes in the striatum. Recently, we have demonstrated the presence of the estrogen-synthesizing enzyme aromatase in the developing mouse striatum. This study is concerned with the expression of estrogen receptor-alpha/beta (ER) mRNA in the developing and adult mouse striatum by semiquantitative reverse transcription-polymerase chain reaction. Expression of both ER subtypes occurred already prenatally and further increased until birth. Early postnatally, ER-alpha/beta levels remained high but decreased to lower levels in adults. No sex difference in ER expression was observed. These data together with our previous findings demonstrate the simultaneous expression of both ER subtypes and aromatase in the mouse striatum. It is concluded that estrogen signalling through both nuclear receptors plays a potential role for striatal differentiation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.