Tandem-repetitive noncoding DNA: forms and forces.
Tandem-repetitive noncoding DNA: forms and forces.
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串联重复非编码 DNA：形式和力量。
DOI：
10.1093/oxfordjournals.molbev.a040542
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发表时间：
1989
影响因子：
10.7
通讯作者：
W. Stephan
中科院分区：
文献类型：
--
作者：
W. Stephan
序列依赖的，不平等的交换和基因扩增（滑动复制）的模型已经被刺激，以考虑串联重复的DNA序列的各种结构特征。它表明，DNA的序列是不是由自然选择保持将表现出重复的模式在很宽的范围内的重组率作为结果的相互作用的不平等的交换和滑动复制，过程依赖于序列的相似性。在高交换频率下，模拟中产生的核苷酸模式简单且高度规则，具有串联重复的短的几乎相同的序列。重组率的降低会增加重复单元更长、更复杂的趋势。已经观察到周期性下降到非常低的重组率（比突变率低一个或多个数量级）。在如此低的速率下，大多数序列含有重复序列，这些重复序列具有广泛的亚结构和彼此之间的高度异质性;通常更高阶的结构叠加在串联阵列上。将这些结果与真核生物中已知的串联重复DNA的各种结构特性进行比较，所述光谱范围从简单序列DNA，特别是高变小卫星，到位于低重组的染色体区域中的经典卫星DNA，例如，异染色质
A model of sequence-dependent, unequal crossing-over and gene amplification (slippage replication) has been stimulated in order to account for various structural features of tandemly repeated DNA sequences. It is shown that DNA whose sequence is not maintained by natural selection will exhibit repetitive patterns over a wide range of recombination rates as a result of the interaction of unequal crossing-over and slippage replication, processes that depend on sequence similarity. At high crossing-over frequencies, the nucleotide patterns generated in the simulations are simple and highly regular, with short, nearly identical sequences repeated in tandem. Decreasing recombination rates increase the tendency to longer and more-complex repeat units. Periodicities have been observed down to very low recombination rates (one or more orders of magnitude lower than mutation rate). At such low rates, most of the sequences contain repeats which have an extensive substructure and a high degree of heterogeneity among each other; often higher-order structures are superimposed on a tandem array. These results are compared with various structural properties of tandemly repeated DNAs known from eukaryotes, the spectrum ranging from simple-sequence DNAs, particularly the hypervariable mini-satellites, to the classical satellite DNAs, located in chromosomal regions of low recombination, e.g., heterochromatin.
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串联重复 DNA 的人类阿尔菲家族。
影响因子：
5.6
作者：
ShmooklerReis,RJ;Srivastava,A;Beranek,DT;Goldstein,S
通讯作者：
Goldstein,S
真核生物常见的简单重复聚(dT-dG).聚(dC-dA)在真细菌和古细菌中不存在，在原生动物中也很少见。
影响因子：
10.7
作者：
Morris,J;Kushner,SR;Ivarie,R
通讯作者：
Ivarie,R
影响因子：
10.7
作者：
G. Gutman
通讯作者：
G. Gutman
哺乳动物细胞中同源重组所需的最小同源量。
影响因子：
5.3
作者：
Rubnitz,J;Subramani,S
通讯作者：
Subramani,S
DOI：
10.1073/pnas.83.14.5199
发表时间：
1986-07-01
影响因子：
11.1
作者：
AYARES, D;CHEKURI, L;KUCHERLAPATI, R
通讯作者：
KUCHERLAPATI, R