3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling.
3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling.
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DOI：
10.1016/j.ijpharm.2021.120501
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发表时间：
2021-05-01
影响因子：
5.8
通讯作者：
Repka MA
中科院分区：
文献类型：
--
作者：
Dumpa N;Butreddy A;Wang H;Komanduri N;Bandari S;Repka MA
在过去的十年中，制药技术的进步导致了治疗的个性化。三维打印（3DP）是药物剂型制造中的新兴技术，因为其具有根据患者的需求创建复杂和定制的剂型的潜力。在基于不同功能机制的各种3DP技术中，熔融沉积成型（FDM）3D打印是一种通用且广泛使用的方法，具有数量精确和能够结合不同填充密度等优点。这种方法也是经济的，很容易产生复杂的设计。热熔挤出（HME）是制药业中的一种成熟技术，用于开发在FDM 3D打印中用作“墨辊”或原料的长丝。本文讨论了FDM 3D打印的各个阶段，包括使用HME的原料细丝制备，数字剂型设计，细丝表征和各种新应用以及未来前景。
Advancements in pharmaceutical technologies have led to the personalization of therapies over the last decade. Three-dimensional printing (3DP) is an emerging technique in the manufacturing of pharmaceutical dosage forms because of its potential to create complex and customized dosage forms according to the patient’s needs. Among the various 3DP techniques based on different functioning mechanisms, fused deposition modeling (FDM) 3D printing is a versatile and widely used method with advantages such as precision of quantity and the ability to incorporate different fill densities. This method is also economical and easily produces complex designs. Hot-melt extrusion (HME) is an established technique in pharmaceutical manufacturing that is utilized in the development of filaments which are used as “ink roll” or feedstock material in FDM 3D printing. This review discusses the various stages involved in FDM 3D printing, including feedstock filament preparation using HME, digital dosage form designs, filament characterization, and various novel applications, and future perspectives.
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