Strategies for the treatment of children with acute lymphoblastic leukemia and unfavorable presenting features.

Strategies for the treatment of children with acute lymphoblastic leukemia and unfavorable presenting features.
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患有急性淋巴细胞白血病和不良表现特征的儿童的治疗策略。

DOI:
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发表时间:
1987
期刊:
Haematology and blood transfusion
影响因子:
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通讯作者:
G. Hammond
G. Hammond
中科院分区:
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文献类型:
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作者:
P. Gaynon;P. Steinherz;G. Reaman;W. Bleyer;H. Sather;G. Hammond

文献摘要

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The Childrens Cancer Study Group (CCSG) is an association of over 100 institutions whose members are responsible for the care of the majority of children with neoplastic disease in the United States and Canada. Over the last 30 years, clinical trials have been conducted for children with acute lymphoblastic or undifferentiated leukemia (ALL). The voluminous data collected have permitted the identification of presenting features that are strongly predictive of outcome and maintain this power in multivariate analyses [1, 2]. These include age, lymphoma syndrome, white blood count (wbc), and percent marrow blasts FAB L2 [3, 4].