AUTONOMIC CARDIOVASCULAR CONTROL IN NORMAL AND PREECLAMPTIC PREGNANCY
AUTONOMIC CARDIOVASCULAR CONTROL IN NORMAL AND PREECLAMPTIC PREGNANCY
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DOI：
10.3109/00016349409029402
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发表时间：
1994-10-01
影响因子：
4.3
通讯作者：
LINDBLAD, LE
中科院分区：
文献类型：
--
作者：
ENEROTHGRIMFORS, E;WESTGREN, M;LINDBLAD, LE
背景资料。子痫前期被认为是一种原发的胎盘紊乱，胎盘位置缺陷会导致内皮和心血管功能紊乱。有证据表明，在这种情况下，神经心血管控制障碍，以及其他高血压疾病。本研究的目的是无创性地评估正常妊娠和先兆子痫妊娠期间的交感迷走神经平衡。对12名健康孕妇、13名子痫前期妇女和10名非妊娠对照组的心率、血压和呼吸运动进行记录，并记录在磁带录音机上进行离线分析。心率、血压和呼吸运动的变异性由自回归频谱分析算法计算。心率变异性以频谱曲线下面积表示，对数值进行t检验。心率变异性包含两个主要的功率成分，一个主要由交感神经张力引起的低频峰值，以及一个反映迷走神经张力的高频峰值。与健康孕妇(p=0.03)和非妊娠妇女(p=0.02)相比，子痫前期妇女的高频峰值显著降低。在低频段，两组之间的功率没有显着差异。血压变异性在两组之间没有差异。目前的结果表明，先兆子痫与心脏迷走神经控制能力下降有关。此外，结果表明，孕酮不改变交感-迷走神经的平衡。
Background. Pre-eclampsia is regarded as a primary placental disorder, in which defect placentation causes endothelial and cardiovascular disturbances. Evidence of disturbed neural cardiovascular control in this condition has been suggested, as well as in other hypertensive diseases. The purpose of the present study was to non-invasively evaluate the sympathovagal balance during normal and pre-eclamptic pregnancy.Methods. In twelve healthy pregnant women, thirteen pre-eclamptic women and ten nonpregnant controls, heart rate, blood pressure and breathing movements were registered and recorded on a tape recorder for off-line analysis. Variability in heart rate, blood pressure and breathing movements were computed by an autoregressive spectral analysis algorithm. Heart rate variability was quantitated as the area under the spectral curve, and Student's t-test was performed on logarithmic values.Results. Heart rate variability contained two major components in power, a low frequency peak predominantly attributed to sympathetic tone, and a high frequency peak reflecting vagal tone. Women with pre-eclampsia were characterized by a significantly reduced high frequency peak compared to healthy pregnant (p = 0.03) and non-pregnant (p = 0.02) women. In the low frequency band there were no significant differences in power between the groups. Blood pressure variability did not differ between the groups.Conclusions. The present results indicate that pre-eclampsia is associated with decreased vagal control of the heart. Furthermore, the results indicate that pregnancy pel se does not change sympatho-vagal balance.