The silent war of CMV in aging and HIV infection.
The silent war of CMV in aging and HIV infection.
复制标题
DOI：
10.1016/j.mad.2015.09.003
复制
发表时间：
2016-09
影响因子：
5.3
通讯作者：
Effros RB
中科院分区：
文献类型：
--
作者：
Effros RB
人巨细胞病毒（CMV），原型β-疱疹病毒，是一种广泛分布的病原体，在骨髓祖细胞中建立终身潜伏感染，也可能在其他细胞中建立。虽然免疫功能正常的个体表现出轻微或无症状，尽管在骨髓细胞分化期间定期再活化，但CMV是老年人和慢性感染HIV的人中相当大的发病率和死亡率的原因。事实上，在这些个体中，CMV的重新激活可能导致严重的并发症。本文将重点介绍CMV在衰老和HIV/AIDS中的作用，特别关注这种持续感染的细胞免疫和与年龄相关的病理结果。将强调长期慢性暴露于CMV抗原对具有复制性衰老特征的CD 8 T细胞扩增的影响。
Human cytomegalovirus (CMV), the prototypical β-herpervirus, is a widespread pathogen that establishes a lifelong latent infection in myeloid progenitor, and possibly other cells as well. Although immunocompetent individuals show mild or no symptoms despite periodic reactivation during myeloid cell differentiation, CMV is responsible for considerable morbidity and mortality in older adults and in persons chronically infected with HIV. Indeed, in these individuals, reactivation of CMV can cause serious complications. This review will focus of the effects of CMV during aging and HIV/AIDS, with particular attention to the cellular immunity and age-related pathology outcomes from this persistent infection. The impact of the long-term chronic exposure to CMV antigens on the expansion of CD8 T cells with features of replicative senescence will be highlighted.