Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression
Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression
复制标题
具有增强成骨分化和血管生成因子表达的可注射纳米结构含硅羟基磷灰石微球
DOI：
10.1016/j.ceramint.2018.08.040
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发表时间：
2018-11-01
影响因子：
5.2
通讯作者：
Lin, Kaili
中科院分区：
文献类型：
--
作者：
Sun, Wenjun;Zhou, Yuning;Lin, Kaili
可注射生物活性陶瓷具有良好的成骨性，在骨再生领域发挥着重要作用。在本研究中，我们创造性地在Na3PO4水溶液中对硅酸钙（CaSiO3）微球进行水热处理，制备了直径为70-100 μ m的可注射纳米结构含硅羟基磷灰石（Si-HAp）微球。用直径为100 nm、长度为1.5 μ m的纳米棒构建Si-HAp微球，与纯HAp微球相比，所制得的纳米结构Si-HAp微球具有优异的蛋白质负载性能和蛋白质持续释放能力。最重要的是，si取代能明显促进大鼠骨髓间充质干细胞（rBMSCs）的增殖、成骨分化和血管生成因子的基因表达。这些都表明，通过水热转化法制备的纳米结构Si-HAp微球有可能作为骨再生的可注射生物活性材料和药物递送材料。
Injectable bioactive ceramics with excellent osteogenesis play important roles in bone regeneration field. In this study, we creatively fabricated the injectable nano-structured silicon-containing hydroxyapatite (Si-HAp) microspheres in diameter of 70-100 mu m via hydrothermal treatment of calcium silicate (CaSiO3) microspheres in Na3PO4 aqueous solution. The fabricated Si-HAp microspheres were constructed by nano-rods with a diameter of 100 nm and length up to 1.5 mu m. Comparing with the pure HAp microspheres, the obtained nano-structured Si-HAp microspheres exhibited excellent protein loading properties and sustained protein release capacities. Most importantly, the Si-substitution could apparently enhance the proliferation, osteogenic differentiation and the genes expression of angiogenic factors of rat bone marrow mesenchymal stem cells (rBMSCs). These all indicated that the nano-structured Si-HAp microspheres fabricated via hydrothermal transformation method might be used as promising injectable bioactive biomaterials and drug deliveries for bone regeneration.