P2RY14 Is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients With Head and Neck Cancer.
P2RY14 Is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients With Head and Neck Cancer.
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P2RY14 是头颈癌患者肿瘤微环境免疫调节和良好预后的潜在生物标志物
DOI：
10.3389/fgene.2021.670746
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发表时间：
2021
影响因子：
3.7
通讯作者：
Guo C
中科院分区：
文献类型：
--
作者：
Li Q;Xu L;Li Y;Yang R;Qiao Q;Wang Y;Wang L;Guo Y;Guo C
肿瘤微环境（tumor microenvironment， TME）在肿瘤的发生、进展和治疗反应中起着至关重要的作用。然而，癌症生物学和TME之间的确切相互作用尚未完全了解。下面的研究使用生物信息学方法分析了头颈部鳞状细胞癌（HNSC）的免疫/基质/估计评分与生存预后的相关性。结果，发现了一种预测性生物标志物，即udp -葡萄糖特异性G(i)蛋白偶联P2Y受体（P2RY14）。随后研究了p2ry14驱动的信号通路在TME免疫重塑中的潜在作用。简而言之，低免疫评分与HNSC患者预后和临床分期不良、肿瘤大小较大、P2RY14下调相关。此外，生存分析显示，TCGA数据库和我们自己的患者中，高表达的HNSC患者比低表达的HNSC患者生存时间更长。我们进一步发现P2RY14参与HNSC TME的免疫活性；P2RY14的下调导致其成为TME状态转换的一个指标（从免疫显性状态到代谢显性状态）。与P2RY14共表达基因的交叉分析表明，t细胞受体信号通路和PD-L1表达及PD-1检查点通路是P2RY14基因在HNSC中驱动的候选信号通路。进一步研究P2RY14调控的免疫相关信号通路可能有助于HNSC患者获得更高的免疫治疗益处。
The tumor microenvironment (TME) has a crucial role in tumor development, progression, and treatment response. Yet, the exact interaction between cancer biology and the TME is not fully understood. The following study analyzed the correlation between immune/stromal/estimate scores and survival prognosis in head and neck squamous cell carcinoma (HNSC) using a bioinformatic method. As a result, a predictive biomarker, UDP-glucose-specific G(i) protein-coupled P2Y receptor (P2RY14), was discovered. The potential role of P2RY14-driven signaling pathways in the immune-remodeling of TME was then investigated. Briefly, low immune scores were associated with unfavorable prognosis and clinical-stage, larger tumor size, and the down-regulation of P2RY14 in HNSC patients. In addition, the survival analysis showed that HNSC patients with high expression had longer survival than patients with low expression from both TCGA databases and our own patients. We further discovered that P2RY14 is involved in the immune activity in the TME of HNSC; a downregulation of P2RY14 resulted in being an indicator for the conversion of TME status (from immune-dominant to metabolic-dominant status). The intersection analysis of genes co-expressed with P2RY14 indicated that the T-cell receptor signaling pathway and PD-L1 expression and PD-1 checkpoint pathway were candidate signaling pathways driven by the P2RY14 gene in HNSC. Further investigation of immune-associated signaling pathways regulated by P2RY14 may help HNSC patients gain higher immunotherapy benefits.
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影响因子：
4.8
作者：
Jokela, Tiina A.;Karna, Riikka;Tammi, Markku I.
通讯作者：
Tammi, Markku I.
影响因子：
3.5
作者：
Wang H;Wang X;Xu L;Zhang J;Cao H
通讯作者：
Cao H
DOI：
10.18632/aging.101415
发表时间：
2018-04-16
期刊：
Aging
影响因子：
--
作者：
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通讯作者：
Liu Y
影响因子：
15.9
作者：
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通讯作者：
Lee, Byeong Chel
影响因子：
4.4
作者：
Arase, Toru;Uchida, Hiroshi;Maruyama, Tetsuo
通讯作者：
Maruyama, Tetsuo