Genetic Susceptibility to Type 2 Diabetes: A Global Meta-Analysis Studying the Genetic Differences in Tunisian Populations
Genetic Susceptibility to Type 2 Diabetes: A Global Meta-Analysis Studying the Genetic Differences in Tunisian Populations
复制标题
DOI：
10.3378/027.084.0405
复制
发表时间：
2012-08-01
期刊：
影响因子：
--
通讯作者：
Benammar-Elgaaied, Amel
中科院分区：
文献类型：
--
作者：
Berhouma, Rym;Kouidhi, Soumaya;Benammar-Elgaaied, Amel
本研究是首次对来自突尼斯几个地区的人群中2型糖尿病(T2D)相关基因的多态进行荟萃分析。事实上，我们通过荟萃分析结合先前对突尼斯北部、中部或南部人群的研究数据，评估了以下七个基因-PPARg(Pro12Ala)、TNFα(-308a/G)、ENPP1(K121Q)、TCF7L2(rs7903146度C/T)、MTHFR(C677T)、ACE(I/D)和CAPN10(3R/2R)-对T2D风险的影响。采用R统计量2.12.1版软件对研究间的异质性进行估计。如果研究之间不存在异质性，则采用Mantel-Haenszel的固定效应法计算合并优势比。尽管在许多基因座上发现了相似之处，但Woolf检验表明，ENPP1和ACE基因座在T2D风险中的贡献取决于相关群体的地理来源，这种异质性不仅可以归因于T2D风险变异的不同贡献，还可以归因于受试组之间遗传背景的差异。有趣的是，观察到的异质性突出了关于Y染色体和线粒体DNA关于突尼斯人口遗传结构的发现，并再次证明突尼斯人和北非人一样是亚群的马赛克，在遗传结构上存在显著差异。在同质性组中，我们复制了TCF7L2、MTHFR、CAPN 10、肿瘤坏死因子α和ACE基因的单核苷酸多态与突尼斯人群中T2D风险的关联，OR范围从1.43到6.72。然而，我们报告在突尼斯人群中没有PPARg与T2D的关联。
The present study is the first meta-analysis to evaluate type 2 diabetes (T2D)- associated polymorphisms in cohorts originated from several Tunisian regions. In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF alpha (-308A/G), ENPP1(K121Q), TCF7L2(rs7903146 degrees C/T), MTHFR(C677T), ACE(I/D), and CAPN10(3R/2R)-on T2D risk, through a meta-analysis combining data of previous studies performed on Tunisian populations originating from the north, center, or south of the country. R statistics version 2.12.1 software was used to estimate the heterogeneity between studies. Pooled odds ratios were computed by the fixed-effects method of Mantel-Haenszel if no heterogeneity between studies exists. Despite the similarities founded in a number of loci, the Woolf test reported that the contributions of ENPP1 and ACE loci in T2D risk are dependent on the geographic origin of concerned groups, and this heterogeneity could be attributed not only to the variable contribution of the variant in T2D risk but also to diversities of genetic background between tested groups. Interestingly, observed heterogeneity highlighted founding concerning Y chromosome and the mitochondrial DNA about the genetic structure of Tunisian population and proves once again that Tunisians, like the north-Africans, are a mosaic of subpopulations, with significant differences in genetic structure. In homogeneous groups, we replicated the association of single-nucleotide polymorphisms of TCF7L2, MTHFR, CAPN 10, TNF alpha, and ACE genes with a T2D risk in the Tunisian population with OR ranging from 1.43 to 6.72. However, we reported an absence of the association of PPARg with T2D in the Tunisian population.