The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat.
The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat.
复制标题
新型血管活性激素肾上腺髓质素可抑制大鼠的饮水。
作者：
T. Murphy;W. Samson
这种新型激素——肾上腺髓质素（AdM），在外周发挥有效的降血压作用，在肾脏中发挥利尿钠作用，被发现具有抗体力作用。脑室注射 AdM（22、44 和 88 pmol）会导致随后中枢注射 100 pmol 血管紧张素 II 后饮水量出现剂量相关的减少。此外，88 pmol AdM 显着抑制对过夜缺水和高渗挑战的饮水反应。未观察到所测试剂量的 AdM 对血压、心率或运动活动有显着影响。这些结果表明，这种新型激素可以在神经系统内发挥作用，以补充其对液体和电解质稳态的外周作用，而不依赖于对心血管功能或运动的中枢作用。
The novel hormone, adrenomedullin (AdM), which exerts potent hypotensive effects in the periphery and natriuretic actions in the kidney, was found to be antidipsogenic. Cerebroventricular injection of AdM (22, 44, and 88 pmol) resulted in a dose-related diminution of water drinking in response to subsequent central administration of 100 pmol angiotensin II. Additionally, 88 pmol AdM significantly inhibited the drinking response to overnight water deprivation and hyperosmotic challenge. No significant effects of AdM in the doses tested were observed on blood pressure, heart rate, or motor activity. These results suggest that this novel hormone can act within the nervous system to complement its peripheral actions on fluid and electrolyte homeostasis, independent of a central action on cardiovascular function or locomotion.