The use of natural products to target cancer stem cells.
The use of natural products to target cancer stem cells.
复制标题
DOI：
--
复制
发表时间：
2017
影响因子：
5.3
通讯作者：
Wesley F Taylor;E. Jabbarzadeh
中科院分区：
文献类型：
--
作者：
Wesley F Taylor;E. Jabbarzadeh
癌症干细胞假说已被用来解释许多癌症并发症导致不良的患者结果，包括诱导耐药性，转移到远处器官，和肿瘤复发。虽然癌症干细胞模型的有效性仍然是许多科学争论的原因，但已经鉴定了许多推定的癌症干细胞标志物，使得关于癌症干细胞靶向的研究成为可能。在这篇综述中，已经概述了癌症干细胞的一些识别特性，包括有助于在假定的癌症干细胞中通常观察到的耐药性和转移潜力的特性。由于癌症干细胞的多种存活机制、癌症类型和组织之间癌症干细胞标志物的多样性以及癌症干细胞标志物在健康干细胞和体细胞中的普遍性，目前使用的治疗可能将继续无法根除癌症干细胞。癌症干细胞的成功治疗将依赖于能够同时影响许多细胞机制的抗肿瘤药物的开发，以防止这种逃避亚群的存活。天然化合物代表了历史上丰富的新型生物活性化合物来源，这些化合物能够与大量细胞靶标相互作用，同时限制通常与癌症治疗相关的疼痛副作用。还简要回顾了已被证明可以减少癌症干细胞的临床破坏性特性或诱导癌症干细胞死亡的天然产物。
The cancer stem cell hypothesis has been used to explain many cancer complications resulting in poor patient outcomes including induced drug resistance, metastases to distant organs, and tumor recurrence. While the validity of the cancer stem cell model continues to be the cause of much scientific debate, a number of putative cancer stem cell markers have been identified making studies concerning the targeting of cancer stem cells possible. In this review, a number of identifying properties of cancer stem cells have been outlined including properties contributing to the drug resistance and metastatic potential commonly observed in supposed cancer stem cells. Due to cancer stem cells' numerous survival mechanisms, the diversity of cancer stem cell markers between cancer types and tissues, and the prevalence of cancer stem cell markers among healthy stem and somatic cells, it is likely that currently utilized treatments will continue to fail to eradicate cancer stem cells. The successful treatment of cancer stem cells will rely upon the development of anti-neoplastic drugs capable of influencing many cellular mechanisms simultaneously in order to prevent the survival of this evasive subpopulation. Natural compounds represent a historically rich source of novel, biologically active compounds which are able to interact with a large number of cellular targets while limiting the painful side-effects commonly associated with cancer treatment. A brief review of select natural products that have been demonstrated to diminish the clinically devastating properties of cancer stem cells or to induce cancer stem cell death is also presented.