Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice.
Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice.
复制标题
消除产前接触己烯雌酚对雌激素受体-α基因敲除小鼠情绪行为的性别依赖性影响。
DOI：
10.1097/01.wnr.0000224771.82151.77
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Ogawa,Sonoko
中科院分区：
文献类型：
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作者：
Tomihara,Kazuya;Kaitsuka,Taku;Soga,Tomoko;Korach,KennethS;Pfaff,DonaldW;Takahama,Kazuo;Ogawa,Sonoko
为探讨雌激素受体α在孕期暴露于己烯雌酚对情绪性影响中的作用，对雌激素受体α基因敲除杂合子妊娠小鼠在妊娠11~17天经口给予0.1μg/只己烯雌酚。在野生型雌性小鼠中，己烯雌酚显著减少了在亮区的时间(即情绪性的降低)，而在野生型雄性小鼠中，己烯雌酚处理后这一测量结果有增加的趋势(即情绪性的增加)。在雌激素受体-α基因敲除小鼠中，己烯雌酚的这些性别依赖效应被完全消除。这些结果表明，己烯雌酚对情绪性的性别依赖性作用主要是通过其对雌激素受体α的作用产生的。
To investigate the contribution of estrogen receptor-α in the effects of prenatal exposure to diethylstilbestrol on emotionality, estrogen receptor-α knockout heterozygous pregnant mice were orally given 0.1 μg/animal of diethylstilbestrol from gestational day 11 to 17. Emotional behavior of the offspring was assessed at 5 weeks in light–dark transition tests. Time spent in the light area was significantly decreased (ie decrease of emotionality) by diethylstilbestrol exposure in wild-type female mice, whereas in wild-type male mice this measurement tended to be increased (ie increase of emotionality) by diethylstilbestrol treatment. These sex-dependent effects of diethylstilbestrol were completely abolished in estrogen receptor-α knockout mice. These results suggest that the sex-dependent effects of diethylstilbestrol on emotionality are mainly produced by its action on estrogen receptor-α.