Role of the thymus in directing the development of a subset of B lymphocytes
Role of the thymus in directing the development of a subset of B lymphocytes
复制标题
胸腺在指导 B 淋巴细胞亚群发育中的作用
DOI：
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发表时间：
1982
影响因子：
15.3
通讯作者：
W. Paul
中科院分区：
文献类型：
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作者：
J. Mond;I. Scher;J. Cossman;S. Kessler;P. Mongini;C. Hansen;F. Finkelman;W. Paul
为了评估胸腺在影响LYB-5-B淋巴细胞发育中的作用，研究了同时表达xid和nu基因缺陷的小鼠。表达其中任何一种缺陷的小鼠对三硝基苯基化流产布鲁氏菌和脂多糖都有反应；而联合缺陷的小鼠表现出明显的抑制反应。其他异常包括：(A)血清Ig水平下降超过80%；(B)sIgM+sIgD-B淋巴细胞数量显著增加；(C)sIgD+细胞上IGD表达减少；(D)其淋巴组织组织学显著异常。由于不表达XID缺陷的nu/nu小鼠看起来相对正常，这表明LYB-5-B淋巴细胞的发育需要胸腺的影响才能正常成熟，而LYB-5+B淋巴细胞相对独立于这种影响。
In an effort to evaluate the role of the thymus in influencing the development of Lyb-5- B lymphocytes, mice expressing both the xid and nu gene defects were studied. Mice expressing either of these defects respond to both trinitrophenylated Brucellus abortus and lipopolysaccharide; whereas mice with the combined defect show markedly suppressed responses. The other abnormalities included: (a) greater than 80 percent diminution of serum Ig levels; (b) significant increase in the number of sIgM+ sIgD- B lymphocytes; (c) reduced expression of IgD on sIgD+ cells; and (d) a strikingly abnormal histology of their lymphoid tissue. Because nu/nu mice that do not express the xid defect appear relatively normal, it would suggest that the development of Lyb- 5- B lymphocytes require a thymic influence for normal maturation, whereas, Lyb-5+ B lymphocytes are relatively independent of such influences.