Cholest‐5‐ene‐3β,26‐diol: Synthesis and biomedical use of a deuterated compound
Cholest‐5‐ene‐3β,26‐diol: Synthesis and biomedical use of a deuterated compound
复制标题
Cholest-5-ene-3β,26-二醇：氘代化合物的合成和生物医学用途
DOI：
--
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
F. H. Field
中科院分区：
文献类型：
--
作者：
N. Javitt;E. Kok;J. Lloyd;A. Benscath;F. H. Field
为了进一步研究26-羟基胆固醇在胎儿和新生儿体内的代谢，以氪黄素为原料，经Clemmensen还原反应合成了氘代化合物。氘代26-羟基胆固醇的光谱显示，每个26-羟基胆固醇分子掺入5至9个氘原子，最多掺入8个氘原子。经口给药后，从儿童粪便中回收的氘代化合物未发生变化。氘代化合物与氚化合物的比率的比较表明存在26-羟基胆固醇的内源性库。向仓鼠胃肠外给予化合物表明代谢为氘代鹅去氧胆酸。该化合物可用作研究26-羟基胆固醇内源性代谢的同位素示踪剂。
To further studies of the metabolism of 26-hydroxycholesterol in fetal and neonatal life, a deuterated compound was prepared from kryptogenin by Clemmensen reduction. The spectra of the deuterated 26-hydroxycholesterol showed that five to nine deuterium atoms were incorporated per 26-hydroxycholesterol molecule, with the maximum incorporation of eight deuterium atoms. The deuterated compound was recovered unchanged from the feces of a child following oral administration. Comparison of the ratio of deuterated to protium compound indicated the presence of an endogenous pool of 26-hydroxycholesterol. Parenteral administration of the compound to a hamster indicated metabolism to deuterated chenodeoxycholic acid. The compound is useful as an isotope tracer for studies of the endogenous metabolism of 26-hydroxycholesterol.
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kok,E;Burstein,S;Javitt,NB;Gut,M;Byon,CY
通讯作者：
Byon,CY