Differential effects of damage within the hippocampal region on memory for a natural, nonspatial odor-odor association
Differential effects of damage within the hippocampal region on memory for a natural, nonspatial odor-odor association
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DOI：
10.1101/lm.38201
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发表时间：
2001-03-01
影响因子：
2
通讯作者：
Eichenbaum, H
中科院分区：
文献类型：
--
作者：
Alvarez, P;Lipton, PA;Eichenbaum, H
关于啮齿动物海马体在记忆中的作用是否仅限于空间领域的争论仍在继续。最近，这一争议在食物偏好的社会传递研究中得到了解决，这是一个没有空间要求的气味-气味关联任务，许多报告得出结论，海马区域的损伤会损害该任务中的记忆，但关于产生损害的必要损伤程度仍然存在疑问。此外，最近的一个种马！（Burton et al. 2000）在这项任务中没有发现海马损伤对记忆的影响。我们对海马完全损伤(H)、海马加下带损伤（HS）和邻近解剖相关的海马旁区（PHR）皮层损伤的动物进行了实验。H损伤对空间延迟交替产生损害，但对食物偏好社会传递的记忆没有损害，而HS和PHR损伤对社会获得性食物偏好的记忆产生严重且相当的损害。我们讨论了与Burton等人（2000）的结果差异的可能解释，并得出结论，海马体和下托共同在这种非空间、关系记忆的形成中起着关键作用。
Debate continues on whether the role of rodent hippocampus in memory is limited to the spatial domain. Recently, this controversy has been addressed with studies on the social transmission of food preference, an odor-odor association task with no spatial requirements, Multiple reports have concluded that damage to the hippocampal region impairs memory in this task, but there remain questions about the extent of damage essential to produce an impairment. Furthermore, a recent stud! (Burton et al. 2000) found no effect of hippocampal] lesions on memory in this task. We tested animals with complete lesions of the hippocampus (H) lesions of the hippocampus plus subiculum (HS), and lesions of the adjacent, anatomically related cortices of the parahippocampal region (PHR). H lesions produced an impairment on spatial delayed alternation, but not on memory for the social transmission of food preference, whereas HS and PHR lesions produced severe and equivalent impairments on memory for the socially acquired food preference. We discuss possible explanations for the discrepancy with the results of Burton et al. (2000) and conclude that the hippocampus and subiculum together play a critical role in the formation of this form of nonspatial, relational memory.