Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
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DOI：
10.1016/s0959-437x(96)80048-7
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发表时间：
1996-04-01
影响因子：
4
通讯作者：
Allis, CD
中科院分区：
文献类型：
--
作者：
Brownell, JE;Allis, CD
核心组蛋白氨基末端尾的翻译后乙酰化长期以来与染色质组装和基因表达调控相关。最近组蛋白乙酰转移酶基因的鉴定和克隆是我们理解特定乙酰化状态是如何建立的一个重大突破。这些酶及其分子组的持续表征支持乙酰化在调节染色质结构以产生新的转录模式的信号传导途径中的直接作用。
Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.