Opioid and chemokine receptor crosstalk: a promising target for pain therapy?
Opioid and chemokine receptor crosstalk: a promising target for pain therapy?
复制标题
DOI：
10.1038/nrn3858
复制
发表时间：
2015-02-01
影响因子：
34.7
通讯作者：
Goazigo, Annabelle Reaux-Le
中科院分区：
文献类型：
--
作者：
Parsadaniantz, Stephane Melik;Rivat, Cyril;Goazigo, Annabelle Reaux-Le
趋化因子和阿片样物质是外周和中枢疼痛通路中免疫、炎症和神经元反应的重要调节因子。最近的研究为趋化因子受体和阿片受体之间的功能相互作用及其在疼痛调节中的作用提供了见解。在这篇进展文章中，我们讨论了这两个系统之间的相互作用如何为开发用于治疗急性和/或慢性疼痛的新型镇痛疗法提供分子和细胞框架。
Chemokines and opioids are important regulators of immune, inflammatory and neuronal responses in peripheral and central pain pathways. Recent studies have provided insights into the functional interactions between chemokine receptors and opioid receptors, and their role in pain modulation. In this Progress article, we discuss how crosstalk between these two systems might provide a molecular and cellular framework for the development of novel analgesic therapies for the management of acute and/or chronic pain.